Urology News Feeds

Is Extraprostatic Extension of Cancer Predictable? A Review of Predictive Tools and an External Validation based on a Large and a Single Center Cohort of Prostate Cancer Patients

Urology (Gold Journal) In Press - Wed, 03/27/2019 - 00:00
Our aim was to review and externally validate all the available predictive tools (PTs) predicting EPE using the area under the curve (AUC), calibration plots and scaled brier score.A literature search was performed showing 19 models predicting EPE. External validation (EV) was carried out on 6360 prostate cancer (PCa) patients submitted to RP. Most of the PTs showed poor discrimination and unsatisfactory calibration.The majority of the available PTs are not reliable for the prediction of EPE in populations other than the development one; thus, they may not be completely appropriate for patients’ counselling or for surgical strategy preplanning.
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Location of recurrence by Gallium-68 PSMA-11 PET scan in prostate cancer patients eligible for salvage radiotherapy

Urology (Gold Journal) In Press - Wed, 03/27/2019 - 00:00
To identify locations of recurrence after radical prostatectomy (RP) with PSA <2 by Gallium-68 Prostate Specific Membrane Antigen (PSMA)-11 PET imaging, and to determine whether standard nodal radiation fields would cover the location of prostate cancer recurrence.
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“The Utility of Prostate Specific Antigen Density, Prostate Health Index and Prostate Health Index Density in Predicting Positive Prostate Biopsy Outcome is Dependent on the Prostate Biopsy Methods”

Urology (Gold Journal) In Press - Tue, 03/26/2019 - 00:00
To evaluate prognostic markers, prostate-specific antigen (PSA), prostate health index (PHI) and prostate volume indexed measures (PSAD and PHID) for predicting positive prostate cancer biopsies in magnetic resonance (MR) transrectal ultrasound fused versus non-fused transrectal ultrasonography biopsy.
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Right Testicular Infarction Secondary to Spontaneous Testicular Vein Thrombosis in a Child: Case Report and Literature Review

Urology (Gold Journal) In Press - Tue, 03/26/2019 - 00:00
Pediatric testicular vein thrombosis is a rare entity with only six reported cases. Diagnosis depended on preoperative clinical suspicion, radiological and intraoperative findings. The literature is very limited in the pediatric population with different etiologies and different managements. We present a case of a 14-year-old boy who suffered from spontaneous right testicular vein thrombosis and was treated with right orchiectomy and oral anticoagulation. We also reviewed and summarized the previously described cases of pediatric testicular vein thrombosis.
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Botulinum toxin type A injection after failure of augmentation enterocystoplasty performed for neurogenic detrusor overactivity: preliminary results of a salvage strategy. The ENTEROTOX study

Urology (Gold Journal) In Press - Tue, 03/26/2019 - 00:00
To evaluate the clinical efficacy, urodynamic effect and safety of Botulinum Toxin A (BTXA) injections after failure of augmentation enterocystoplasty (AE) performed for NDO.
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Whole Exome Sequencing Identifies a Rare Nonsense Mutation in FAM47C as a Possible Cause of Severe Oligospermia in Brothers with Varicocele

Urology (Gold Journal) In Press - Mon, 03/25/2019 - 00:00
Varicocele is a common cause of impaired semen parameters in men with infertility. Here, we investigated genetic variants as possible causes of varicocele with impaired semen parameters using whole-exome sequencing (WES) in a family with 2 brothers with severe oligospermia, 1 unaffected brother, father, and the mother. Results showed a premature stop codon alteration on Chromosome X (37028866 CT) in the gene FAM47C. The affected brothers were found to be hemizygous for the variant, while the mother was a heterozygous carrier.
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Avoiding the Need for Bowel Anastomosis during Pelvic Exenteration—Urinary Sigmoid or Descending Colon Conduit—Short and Long Term Complications

Urology (Gold Journal) In Press - Mon, 03/25/2019 - 00:00
To educate surgeons of distal colon urinary diversion as an alternative to ileal conduit. To assess peri-operative outcomes of distal colon conduit in pelvic exenteration including conduit-related, gastrointestinal, infectious, metabolic, and wound complications within 30 days, 31-89 days, and greater than 90 days from the time of surgery.
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A Novel Proteomics Approach to Identify Serum and Urinary Biomarkers and Pathways that Associate with Lower Urinary Tract Symptoms in Men and Women: Pilot Results of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Study

Urology (Gold Journal) In Press - Mon, 03/25/2019 - 00:00
To assess the feasibility of a novel proteomics approach to identify biomarkers associated with LUTS within serum and urine, because many clinical factors contribute to lower urinary tract symptoms (LUTS) in men and women. These factors confound clinicians’ abilities to reliably evaluate and treat LUTS. Previous studies identified candidate LUTS biomarkers, but none are clinically utilized.
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A Rare Cause of Urinary Peritonitis: Intra-abdominal Adhesion Rupture

Urology (Gold Journal) In Press - Mon, 03/25/2019 - 00:00
Intra-abdominal adhesions are a common complication following any surgical procedure involving the abdominopelvic cavity. The mechanism behind adhesion formation is still not well understood, however is thought to be caused from inflammatory signaling and mesothelial surface disruption.1 Adhesion occurrence following a laparotomy is estimated to be as high as 95%1 with the other two main causes of adhesion formation being chronic inflammation of the bowel and post radiation therapy.2,3,4 Bladder perforation due to intra-abdominal adhesions has never been reported but may be something to consider when other causes of peritonitis have been excluded.
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Perioperative Hypoxia Secondary to Phenazopyridine-Induced Methemoglobinemia in an Adolescent Patient Without Renal Insufficiency or Overdose: An Unusual Case

Urology (Gold Journal) In Press - Sun, 03/24/2019 - 00:00
Phenazopyridine is a common, well tolerated medication with minimal side effects. Severe side effects are rare and include methemoglobinemia in setting of overdose, elderly patients, renal insufficiency and chronic use.Here we report a case of methemoglobinemia induced perioperative hypoxia in an adolescent patient without renal insufficiency or overdose which has not been reported previously. This case underscores the importance of judicious use of this medication in all patients but notably in pediatric patients and those with chronic lung disease.
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Baseline basal cell hyperplasia is not associated with baseline lower urinary tract symptoms, baseline clinical prostatitis or prostate cancer in repeat biopsies

Urology (Gold Journal) In Press - Sat, 03/23/2019 - 00:00
To evaluate whether the presence of BCH in negative biopsies is associated with concurrent lower urinary tract symptoms(LUTS) and BPH, clinical prostatitis and future prostate cancer (PCa) in repeat prostate biopsy.
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Genetic Testing Proves Crucial in Case of Ambiguous Genitalia and Renal Masses

Urology (Gold Journal) In Press - Sat, 03/23/2019 - 00:00
The Denys-Drash syndrome consists of a triad of ambiguous genitalia, Wilm's tumor and nephrotic syndrome. We present a diagnostically challenging case of an XY patient with female appearance and Müllerian structures with a WT1 mutation resulting in gonadal dysgenesis, end-stage renal disease, and precursor changes to Wilm's tumor in both kidneys. Genetic testing proved critical in this case, helping to solidify a diagnosis and guiding our decision to proceed with bilateral nephrectomy and bilateral gonadectomy.
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OUTCOMES OF PARTIAL AND RADICAL NEPHRECTOMY IN OCTOGENARIANS – A MULTICENTER INTERNATIONAL STUDY (RESURGE)

Urology (Gold Journal) In Press - Sat, 03/23/2019 - 00:00
To analyze the outcomes of partial nephrectomy (PN) and radical nephrectomy (RN) in octogenarian patients.
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A Comparison of Hemostatic Patches versus Pericardium Allograft for the Treatment of Complex Peyronie's Disease with Penile Prosthesis and Plaque Incision

Urology (Gold Journal) In Press - Sat, 03/23/2019 - 00:00
To compare outcomes between hemostatic patches (HP) versus pericardium allografts (PA) for complex Peyronie's disease with erectile dysfunction managed with inflatable penile prosthesis (IPP) and plaque incision and grafting (PIG).
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Safety and Efficacy of Collagenase Clostridium Histolyticum in Peyronie's Disease Men with Ventral Curvatures

Urology (Gold Journal) In Press - Fri, 03/22/2019 - 00:00
To evaluate the safety and efficacy of collagenase clostridium histolyticum (CCH) in men with ventral penile curvatures secondary to Peyronie's Disease (PD).
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Whole-Exome Sequencing Identifies Novel Heterozygous Mutation in RAF1 in Family with Neonatal Testicular Torsion

Urology (Gold Journal) In Press - Wed, 03/20/2019 - 00:00
To investigate a genetic cause of neonatal testicular torsion in two siblings and paternal cryptorchidism in a Caucasian family without history of consanguinity, we performed whole exome sequencing
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Free-Floating Paratesticular Calcifying Fibrous Pseudotumors in a Pediatric Patient

Urology (Gold Journal) In Press - Wed, 03/20/2019 - 00:00
Paratesticular masses are a relatively common finding in males. The majority are benign, as opposed to testis masses, which tend to be malignant. Fibrous pseudotumors are rare, but are the third most common paratesticular tumor after adenomatoid and lipoma. The exact cause is unclear but likely from a fibroinflammatory reaction. Because of the non-specific findings on physical exam and scrotal ultrasound, patients may undergo scrotal exploration and occasionally orchiectomy, in spite of the benign nature of this lesion.
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Surgical Experience with Genital and Perineal Extramammary Paget's Disease

Urology (Gold Journal) In Press - Tue, 03/19/2019 - 00:00
To describe our surgical experience for the treatment and management of extramammary Paget's disease (EMPD).
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Complete ultrasound-guided percutaneous nephrolithotomy in prone and supine positions: A Randomized controlled study

Urology (Gold Journal) In Press - Tue, 03/19/2019 - 00:00
To evaluate the safety, efficacy, adverse events and feasibility of ultrasound guided percutaneous nephrolithotomy (US-PCNL) in the management of large renal stones in supine and prone positions and to point out the practical considerations related to these techniques in comparison with standard PCNL.
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Three cases of testicular adrenal rest tumors in congenital adrenal hyperplasia - a diagnostic and therapeutic challenge

Urology (Gold Journal) In Press - Mon, 03/18/2019 - 00:00
A 23-year old man presented with massive enlargement of his testes. He had a known history of salt-wasting congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) and was on glucocorticoid and mineralocorticoid replacement since initial diagnosis at birth with a current treatment regimen of prednisolone 7.5 mg and fludrocortisone 75 µg daily. However, compliance was poor as reflected by hormonal control parameters out of target range (Table 1). Ultrasound of the testes revealed the presence of massive bilateral tumors with mixed hypo- and hyperechogenic appearance.
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