Urology News Feeds
OVOTESTICULAR DISORDER OF SEX DEVELOPMENT: A RARE CASE OF LATERAL SUBTYPE 45X/46XY KARIOTYPE DIAGNOSED IN ADULTHOOD
A 53-year-old male referred to our Centre because of hypergonadotropic hypogonadism detected during urological follow-up for urethral lithiasis. Physical Examination showed short stature, micropenis, ambiguous external genitalia, normal secondary sexual characteristics. Karyotype: 45 × 0/46XY. Abdominal MRI revealed the presence of uterus-like structure, right annex and left testes without prostate. He underwent laparoscopic removal of dysgenetic tissues; histological examination confirmed the presence of little uterus, fallopian tubes, little atrophic ovary, and vaginal tract; left testes was atrophic with sclero-jalinosis of seminal tubes and Leydig's cells hyperplasia.
To evaluate the feasibility and outcomes of full thickness penile skin grafting (FTSG) for phalloplasty during acquired buried penis repair.
To assess if 'tumour budding' (TB) behaves as a poor prognostic factor in muscle-invasive bladder carcinoma (MIBC). TB is the presence of tumour cells isolated or in small groups of fewer than five cells located at the tumour invasion front.
To evaluate the genetic and environmental relationship among prostatitis and other urological conditions, including benign prostatic hyperplasia (BPH) and prostate cancer (CaP), a classical twin design and biometric modeling was used. While prostatitis – characterized by pain and voiding symptoms, no clear etiology, and functional and quality of life impairments – co-occurs with other urinary conditions, the degree of shared overlapping etiological processes among them remains unclear. We examined the contribution of genetic and environmental factors to these conditions and the etiology of their associations at the level of genetic and environmental influences.
Prostate-specific-membrane-antigen (PSMA) is a transmembrane protein with significantly increased expression in the cells and metastases of prostate carcinoma (PCa). PSMA-expression correlates with higher serum levels of prostate-specific-antigen (PSA) and a higher Gleason Score (GS). This finding has led to the development of novel imaging modalities such as 68Ga-/18F-labeled PSMA PET/CT and PET/MRI. This article reviews the literature pertaining to various new imaging technologies for the management of PCa.
The Incidence and Durability of Compensatory Hypertrophy in Pediatric Patients with Solitary Kidneys
To evaluate the incidence and durability of compensatory hypertrophy with solitary kidneys in the setting of those with multicystic dysplastic kidney or Wilms tumor status post nephrectomy.
Second reported case of pediatric bladder alveolar soft part sarcoma as secondary malignancy after prior cytotoxic chemotherapy
Alveolar soft part sarcoma (ASPS) is a rare malignancy with high rates of metastasis at presentation, defined by an unclear cellular origin and a unique unbalanced ASPSCR1-TFE3 translocation (der(17)t(X:17)(p11:q25))1. ASPS is insensitive to chemotherapy and has been reported to involve the bladder only twice in the pediatric literature; once as a primary malignancy2, and once as a secondary malignancy after cytotoxic chemotherapy3. Herein, we report the third case of pediatric bladder ASPS in a female patient who received cytotoxic chemotherapy for low-risk neuroblastoma.
Use of Office Versus Ambulatory Surgery Center Setting and Associated Ancillary Services on Healthcare Cost Burden for Vasectomy Procedures
To analyze variation in total healthcare costs for vasectomies performed in the United States, based on procedure setting and use of ancillary pathology services.
To demonstrate indications, review tools and techniques, as well as abnormal findings when performing a retrograde pyelogram.
To show how to perform a robot-assisted partial nephrectomy and bilateral pyelolithotomy in ectopic pelvic kidneys. This is a congenital abnormality of position and rotation1 frequently associated with urolithiasis.2 Renal cell carcinoma is a very rare event in pelvic kidneys.3,4 These two findings in the same patient could be a surgical challenge and whenever possible a “one stage” treatment is preferred.
Factors influencing the feasibility of segmental artery clamping during retroperitoneal laparoscopic partial nephrectomy
To investigate factors that may predict successful precise segmental artery clamping during retroperitoneal laparoscopic partial nephrectomy (LPN) for treatment of T1 kidney tumor.
Letter to the Editor on: Bladder Agenesis and Associated Pelvic Arterial Anomaly in 2 Female Pediatric Patients
In their recently published case report, Lowery et al presented two patients with bladder agenesis and concomitant pelvic arterial anomaly and suggested the two anatomical variants are causally related.1 Bladder agenesis is extremely rare with only 25 live births recorded in the literature.2 With so few patients to study, much of what is known is through case reports such as Lowery's.
Editorial Comment/Author Response to "Letter to the Editor on: Bladder Agenesis and Associated Pelvic Arterial Anomaly in 2 Female Pediatric Patients" (#URL-D-19-00427)
Since bladder agenesis is exceedingly rare, it is likely that we will never know the etiology of this malformation, or whether it could be the end result shared by more than one mechanism of maldevelopment. We agree with the authors of the “Letter to the Editor” that most published bladder agenesis cases do not comment on presence or absence of anomalous pelvic arterial anatomy. Thus, the authors are likely correct that the vascular malformation is not the root cause in most bladder agenesis cases.
Contemporary Management of Incident Prostate Cancer in Large Community Urology Practices in the United States
To characterize the contemporary management of prostate cancer patients in large community practices. The optimal management of incident prostate cancer has changed in the last decades to include active surveillance for a large number of men. At the same time, many community practices have merged into larger groups. The adoption of evidence-based guidelines is of increasing importance, but poorly understood in this newer practice setting.
COMPARISON OF PATIENT'S SATISFACTION AND LONG-TERM RESULTS OF TWO PENILE PLICATION TECHNIQUES: LESSONS LEARNED FROM 387 PATIENTS WITH PENILE CURVATURE
To compare the patient's satisfaction and long-term results of two penile plication procedures in patients with penile curvature.
Increasing Utilization of Multi-Parametric Magnetic Resonance Imaging in Prostate Cancer Active Surveillance
To characterize the use of multiparametric magnetic resonance imaging (mpMRI) in male Medicare beneficiaries electing active surveillance for prostate cancer. Multi-parametric resonance imaging (mpMRI) has emerged as a tool that may improve risk-stratification and decrease repeated biopsies in men electing active surveillance. However, the extent to which mpMRI has been implemented in active surveillance has not been established.
To demonstrate technical considerations of a true single port robotic assisted ureteroneocytostomy using the da Vinci SP platform (Intuitive Surgical, Sunnyvale, CA).
A Case of Metastatic Prostate Cancer to the Urethra that Resolved after Androgen Deprivation Therapy
An 83 year-old male with Gleason score 4+3 prostatic adenocarcinoma status post brachytherapy developed obstructive voiding symptoms nine years after brachytherapy. PSA was 0.67. Cystoscopy noted multiple papillary urethral tumors concerning for primary urethral carcinoma. Immunophenotype of biopsies supported diagnosis of Gleason score 4+4 prostatic adenocarcinoma. Androgen deprivation therapy was started. Cystoscopy performed four years later, for microhematuria workup, noted complete resolution of the urethral tumors.
Urethral obstruction due to retained bullets migrating into the genitourinary system has rarely been reported. The literature describes two main methods of retained bullet removal from the genitourinary system: (1) spontaneous expulsion during voiding and (2) manual extraction due to urethral obstruction causing acute urinary retention. We present a case in which a 21-year-old man presented with acute urinary retention three years after suffering a gunshot wound to the abdomen. A retained bullet eroded through the bladder wall, migrated through the bladder and urethra, and eventually became lodged in the external urethral meatus, causing obstruction and urinary retention.
To evaluate the impact of cisplatin-based neoadjuvant chemotherapy (NAC) in patients who underwent nephroureterectomy for high grade (HG) upper tract urothelial carcinoma (UTUC).