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Preoperatively Dilated Ureters are a Specific Risk Factor for the Development of Ureteroenteric Strictures After Open Radical Cystectomy and Ileal Neobladder

Sat, 05/20/2017 - 00:00
To evaluate preoperative ureteral obstruction as risk factor for the development of benign UEAS in patients undergoing open RC and INB diversion.
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Long-Term Treatment with OnabotulinumtoxinA Results in Consistent, Durable Improvements in Health-Related Quality of Life in Patients with Overactive Bladder

Sat, 05/20/2017 - 00:00
To present the long-term effects of repeat onabotulinumtoxinA 100U treatment on health-related quality of life in overactive bladder patients with urinary incontinence who had an inadequate response to/were intolerant of an anticholinergic.
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Prostate Arterial Embolization is a Viable Option for Treating Symptoms of Benign Prostatic Hyperplasia

Sat, 05/20/2017 - 00:00
The need for new minimally invasive techniques to treat lower urinary tract symptoms secondary to benign prostatic hyperplasia is demonstrated by the numerous publications on this subject every year and supported by the American Urological Association.6 Among the recent minimally invasive procedures to be developed in this area are Rezūm (NxTHERA, Maple Grove, Minnesota), UroLift® (NeoTract, Pleasanton, California) and prostate artery embolization. PAE has been accepted as a viable treatment for prostate related hematuria for a number of years with hundreds of cases published in the literature.
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Prostate Arterial Embolization is a Viable Option for Treating Symptoms of Benign Prostatic Hyperplasia

Sat, 05/20/2017 - 00:00
When I was in medical school and contemplating what specialty to enter, one of my mentors strongly advised me to stay away from urology. I can almost hear the words today telling me about a new pill being developed that would shrink the prostate and eliminate all surgeries for benign prostatic hyperplasia (BPH). That pill, finasteride, has undergone its own tumultuous story and clearly was not a panacea for BPH. The overwhelming take home message is that “shrinking the prostate” is not the Holy Grail of treating lower urinary tract symptoms (LUTS).
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Risk factors for daytime or combined incontinence in children with cerebral palsy

Fri, 05/19/2017 - 00:00
To identify risk factors for daytime or combined urinary incontinence (UI) in children with cerebral palsy (CP).
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Association Between Preoperative Albumin Levels and Length of Stay after Radical Cystectomy

Fri, 05/19/2017 - 00:00
Using contemporary population-based epidemiologic data, we measured the relationship between preoperative serum albumin level and hospital length of stay (LOS) after cystectomy and urinary diversion.
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Editorial Comment

Thu, 05/18/2017 - 00:00
The 7-item self-administered AUA-SS has stood the test of time and become a worldwide standard to measure the burden of lower urinary tract symptoms among men with LUTS attributable to BPH. However, in several studies, including this one, men with lower health literacy have had problems understanding and completing AUA-SS. One approach to this problem is an interviewer administered AUA symptom index.1 As outlined in this report, another approach is to develop alternative measures such as FLOW, which are easier for such men to understand.
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Clinical and Psychosocial Predictors of Urologic Chronic Pelvic Pain Symptom Change Over One Year: A Prospective Study from the MAPP Research Network

Thu, 05/18/2017 - 00:00
To examine baseline clinical and psychosocial characteristics that predict 12- month symptom change in men and women with urologic chronic pelvic pain syndromes (UCPPS).
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Editorial Comment

Wed, 05/17/2017 - 00:00
Patients with high risk prostate cancer undergoing active treatment exhibit highly variable oncologic outcomes (reference 8 in article). A North American study suggested a further stratification of these individuals into high and very high risk groups to address this issue (reference 9 in article). This new classification was adopted by the NCCN guidelines.
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Editorial Comment

Wed, 05/17/2017 - 00:00
My previous mentor and chairman, Dr. Fray Marshall, used to speak of times past when renal mass equaled radical nephrectomy. However, numerous studies have demonstrated equivalent cancer specific mortality rates for PN compared to RN for clinical T1 tumors.1 While there is significant data on the deleterious effects of RN compared to PN on renal function and cardiovascular risk, the impact on overall mortality is controversial (reference 14 in article). The current thoughtful, retrospective study by Shah et al demonstrates lower recurrence-free survival for PN vs RN in patients with clinical T1 tumors that are up staged to pathological T3a disease.
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Editorial Comment

Wed, 05/17/2017 - 00:00
Up staging of clinical T1 RCC occurs when tumors invade small branches of renal veins or fat surrounding the kidney. Similar to prior studies (reference 3 in article) Shah et al describe an 11% risk of pathological up staging. Interestingly they found a higher recurrence risk in up staged cases following partial vs radical nephrectomy. After partial nephrectomy most recurrences were local, which may be amenable to curative local therapy and associated with favorable cancer specific survival in the absence of distant metastasis.
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Reply by Authors

Wed, 05/17/2017 - 00:00
We appreciate the comment and recognize the pioneering work of Dr. Parsons in the 1990s (references 1 and 2 in comment). In our preliminary work principal component analysis and unsupervised hierarchical clustering showed a clear separation between gene expression profiles in bladder biopsy tissues from subjects with low capacity (400 ml or less) compared to those with bladder capacity greater than 400 ml (reference 12 in article). These data are consistent with a bladder centric disease phenotype.
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Editorial Comment

Wed, 05/17/2017 - 00:00
These authors report BC while under anesthesia in more than 100 patients with IC. Results show that BC was inversely proportional to patient reported symptoms on several questionnaires and to age. The key message is that patients who are older have more bladder symptoms and lower BC, and we reported similar results.1 This message is critical because it emphasizes that IC is a chronic disease that begins when the symptoms are milder and intermittent. With time symptoms increase and bladder capacity decreases because the disease is destroying the bladder.
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Home Study Course 2017 Volume 197/198

Wed, 05/17/2017 - 00:00
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Re: Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice

Tue, 05/16/2017 - 00:00
W. Ma, S. Li, S. Ma, L. Jia, F. Zhang, Y. Zhang, J. Zhang, G. Wong, S. Zhang, X. Lu, M. Liu, J. Yan, W. Li, C. Qin, D. Han, C. Qin, N. Wang, X. Li and G. F. Gao
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Re: Novel Centrifugal Technology for Measuring Sperm Concentration in the Home

Tue, 05/16/2017 - 00:00
U. Y. Schaff, L. L. Fredriksen, J. G. Epperson, T. R. Quebral, S. Naab, M. J. Sarno, M. L. Eisenberg and G. J. Sommer
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Re: Associations between Physical Activity and Semen Quality in Young Healthy Men

Tue, 05/16/2017 - 00:00
P. Jóźków, M. Mędraś, F. Lwow, A. Zagrodna and M. Słowińska-Lisowska
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When Should we Offer Parasacral Transcutaneous Electrical Nerve Stimulation for Pediatric Patients with Lower Urinary Tract Dysfunction?

Tue, 05/16/2017 - 00:00
Lower urinary tract (LUT) dysfunction in children has a broad spectrum of presentation. Patients may experience symptoms related to overactive bladder (OAB), voiding postponement, dysfunctional voiding (DV) or underactive bladder (UAB). Using the same treatment method will seldom have the same effective action under these different conditions when there are perhaps different pathophysiological etiologies.
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