Urology News Feeds

Variability of Retail Pricing of Generic Urologic Medications in a Major US Metropolitan Area

Urology (Gold Journal) In Press - Tue, 08/28/2018 - 00:00
Objective: To investigate retail pricing for generic urologic medications in the St. Louis area as a function of pharmacy type, zip-code, and median income.Materials and Methods: Pharmacies spanning 51 zip-codes were identified. From May-June 2017, pharmacies were inquired regarding cost, without insurance, for 30- and 90-tablet prices for finasteride 5mg, tamsulosin 0.4mg, oxybutynin 5mg, and oxybutynin ER 5mg and 10mg. Median income was determined using US census data.K-means clustering defined groupings based on zip-code, median income, and a combination of the two.
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Endoscopic robot-assisted simple enucleation vs laparoscopic simple enucleation with single-layer renorrhaphy in localized renal tumors: a propensity score-matched analysis from a high-volume centre

Urology (Gold Journal) In Press - Tue, 08/28/2018 - 00:00
To compare perioperative results and early oncological outcomes of endoscopic robot-assisted simple enucleation (ERASE) and laparoscopic simple enucleation (LSE) by using a propensity score-matched analysis.
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CURRENT STATE OF UROLOGIC MEDICAL SCHOOL EDUCATION: A SCOPING REVIEW

Urology (Gold Journal) In Press - Tue, 08/28/2018 - 00:00
To review current literature pertaining to the availability and implementation of urology-focused curricula, in an effort to highlight current approaches to urologic education at the medical school level.
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Late Relapse of Nonseminomatous Germ Cell Tumor 24 Years Later

Urology (Gold Journal) In Press - Tue, 08/28/2018 - 00:00
A 60 year-old man with a history of coronary artery disease status-post coronary artery bypass graft, hypertension, type II diabetes, current every-day smoker, and testicular cancer presented with abdominal and left flank pain. A CT and PET scan were performed, revealing a PET-avid 5.5 × 4.4 cm left para-aortic and renal hilar mass (Figures 1–2). Serum tumor markers were normal.
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Population Analysis of Male Urethral Stricture Management and Urethroplasty Success in the United States

Urology (Gold Journal) In Press - Tue, 08/28/2018 - 00:00
To examine population-based practice patterns and outcomes related to urethroplasty for urethral stricture management.
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Ten-year outcomes of renal tumor radiofrequency ablation

We sought to review long-term oncological outcomes of patients with renal tumors treated with radiofrequency ablation (RFA) greater than 10 years ago.
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International multi-center validation of an intermediate-risk subclassification of prostate cancer treated with radical treatment without hormone therapy

The NCCN guidelines recently endorsed a subclassification of intermediate-risk prostate cancer (IR-PCa) into favourable (FIR) and unfavourable (UIR) subgroups. However, this subclassification was developed in a treatment-heterogeneous cohort, hence the natural history of androgen deprivation treatment (ADT)-naïve FIR- and UIR-PCa remains unknown.
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Editorial Comment

Imaging has demonstrated growing usefulness for the detection of prostate cancer. Previous data have shown that MRI fusion biopsy improves the identification of clinically significant prostate cancer and reduces the detection of clinically insignificant cancer compared to standard TRUS guided biopsy.1 In this article Simmons et al found that MRI targeted biopsy diagnosed 81% of cases of clinically significant cancer while reducing the diagnosis of clinically insignificant disease by 40% compared to saturation transperineal template biopsy sampling in men in the PICTURE trial requiring repeat biopsy.
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Editorial Comment

This report highlights several important aspects of patients with proximal hypospadias. Although these patients represent only a small portion of the overall hypospadias population, they require special care in view of the associated psychosocial and physical challenges outlined in this article. Several challenges face the reconstructive surgeon. These cases may involve an androgen receptor or converting enzyme deficiency, or a significant deficiency in the quality and quantity of penile skin, glans, urethral plate, corpus spongiosum and corporeal bodies.
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Editorial Comment

Metformin has been proposed to have efficacy in prostate cancer through several putative mechanisms. They include effects on insulin responsive prostate cancers via attenuation of hyperinsulinemia, inhibition of oxidative phosphorylation causing energetic stress in cancer cells and potentially delaying the development of castrate resistant prostate cancer, which hyperinsulinemia can potentiate.1 Retrospective studies have supported the hypothesis that metformin can improve outcomes in patients with prostate cancer (reference 25 in article).
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Excessive Opioid Prescribing After Major Urologic Procedures

Urology (Gold Journal) In Press - Fri, 08/24/2018 - 00:00
To examine the use of prescription opioids in patients undergoing major prostate and kidney operations.
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Predictive validation of a robotic virtual reality simulator: The Tube 3 module for practicing vesicourethral anastomosis in robot-assisted radical prostatectomy

Urology (Gold Journal) In Press - Thu, 08/23/2018 - 00:00
To predict actual performance in real surgery when vesicourethral anastomosis (VUA) is performed in patients after Tube 3 module training of robot-naive surgeons.
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The Association Between Tetrahydrocannabinol and Lower Urinary Tract Symptoms Utilizing the National Health and Nutrition Examination Survey

Urology (Gold Journal) In Press - Wed, 08/22/2018 - 00:00
To further define the relationship between tetrahydrocannabinol (THC) and lower urinary tract symptoms (LUTS), specifically how THC use associates with the frequency of LUTS in young community-dwelling men in the United States.
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Bosniak category III renal cysts caused by crizotinib in an anaplastic lymphoma kinase gene-rearranged non-small cell lung cancer patient

Urology (Gold Journal) In Press - Wed, 08/22/2018 - 00:00
Bosniak category III renal cystic masses are often treated with surgical resection because of high risk of malignancy. Crizotinib is an anaplastic lymphoma kinase (ALK) inhibitor used to treat ALK gene-rearranged non-small cell lung cancer (NSCLC) and reported to be associated with complex renal cyst formation. We herein report a case of Bosniak category III renal cysts occurred in a crizotinib-treated ALK gene-rearranged NSCLC patients. The cysts regressed spontaneously after cessation of crizotinib and we could thus avoid unnecessary surgical resection.
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Microsurgical epididymal cystectomy does not impact upon sperm count, motility or morphology and is a safe and effective treatment for epididymal cystic lesions (ECLs) in young men with fertility requirements

Urology (Gold Journal) In Press - Wed, 08/22/2018 - 00:00
To assess the therapeutic efficacy and safety of microsurgical epididymal cystectomy for the treatment of epididymal cystic lesions (ECLs) in young men with fertility requirements and the impact of this surgery upon sperm quality and epididymal function.
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Recurrent unexplained cystitis due to an ingested foreign body- an extremely rare case

Urology (Gold Journal) In Press - Wed, 08/22/2018 - 00:00
We present the images of a 4-year old male child with history of recurrent unexplained urinary tract infections which was found to be due to an ingested wooden foreign body which had perforated the small bowel into the posterior bladder wall. Such cases are very rare, usually due to domestic abuse or in patients with psychiatric illnesses. The adults usually report early but in children these cases get un-noticed. These patients may present with features of bowel obstruction, perforation, or hematochezia.
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A Case of an Invisible Ureteral Stent

Urology (Gold Journal) In Press - Wed, 08/22/2018 - 00:00
A 35-year-old female presented to the emergency department with fevers and flank pain and was found on CT to have a retained ureteral stent that was placed during emergent ureteral repair 8 years prior. The stent was only faintly visible on CT and was completely radiolucent on fluoroscopy. We believe that the stent's radiopaque coating degraded and was lost after years of exposure to urine. This case suggests that a stent may become undetectable on standard imaging if left in place for a long enough period of time.
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Three-Dimensional Printing in Urology: History, Current Applications, and Future Directions

Urology (Gold Journal) In Press - Wed, 08/22/2018 - 00:00
To review the history, current applications, limitations, and future directions of three-dimensional (3D) printing within the field of urology. 3D printing is an additive manufacturing process in which a 3D model is created using a computer-generated image. This technology is applied by companies to create and test new drugs, design and manufacture instrument prototypes, and create patient-specific models of organs for surgical teaching and planning. A literature review was performed within the Web of Science and PubMed databases from January 2008 to May 2018 using keyword phrases “3D printing” and “urology.” A total of 46 relevant publications were included.
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The 17-gene Genomic Prostate Score Assay Predicts Outcome after Radical Prostatectomy Independent of PTEN Status

Urology (Gold Journal) In Press - Wed, 08/22/2018 - 00:00
To compare the ability of loss of phosphatase and tensin homolog (PTEN) and Genomic Prostate Score assay (GPS) in predicting the biochemical-recurrence (BCR) and clinical-recurrence (CR) after radical prostatectomy (RP) for clinically localized prostate cancer (PCa).
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PI-RADSv2 Category on 3 Tesla Multiparametric Prostate MRI Predicts Oncologic Outcomes in Gleason 3+4 Prostate Cancer on Biopsy

3TmpMRI with PI-RADSv2 scoring is a common tool in prostate cancer (PCa) diagnosis and informs the likelihood of a cancerous lesion. We sought to investigate whether PI-RADSv2 also predicts adverse pathologic (AP) features mainly in patients with biopsy Gleason score (GS) 3+4.
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