Urology News Feeds

Short term changes in urinary relative supersaturation predict recurrence of kidney stones: a tool to guide preventive measures in urolithiasis

Kidney stone disease is characterized by a relatively high rate of recurrence. In our study, we analyzed the association between RSS and the risk of stone recurrence. Additionally, we examined the association between changes in RSS and of urinary composition after 1 week of medical treatment and the risk of recurrence.
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Treatment and Prevention of Recurrent Lower Urinary Tract Infections in Women: A Rapid Review with Practice Recommendations

Recurrent lower urinary tract infections (rUTI) in women are a highly prevalent and burdensome condition for which best practice guidelines for treatment and prevention that minimize harm and optimize well-being are greatly needed. To inform development of practice recommendations, a rapid literature review of original research, systematic reviews, meta-analyses and practice guidelines was conducted.
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Comparison of Elastic and Rigid Registration During Magnetic Resonance Imaging/Ultrasound Fusion-Guided Prostate Biopsy: A Multi-Operator Phantom Study

The relative value of rigid or elastic registration during Magnetic Resonance Imaging (MRI)/Ultrasound (US) fusion guided prostate biopsy (FBx) has been poorly studied. This study compared registration error (RE) between rigid and elastic registration during FBx using a prostate phantom model.
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Polypoid endometriosis presenting as a renal cortical tumor

Urology (Gold Journal) In Press - Thu, 06/21/2018 - 00:00
A 41-year-old female presented with left-sided flank pain and gross hematuria temporally unrelated to her menstrual cycle. Abdominal computed tomography scan showed a large left-sided solid, enhancing kidney mass radiographically consistent with renal cell carcinoma. Following surgical resection, histopathological examination revealed polypoid endometriosis. Polypoid endometriosis is rare and mimics a neoplasm clinically, radiographically, and on gross examination. Patients with polypoid endometriosis often present with symptoms related to mass effect rather than classic endometriosis hallmark symptoms such as dyspareunia, dysmenorrhea, and cyclic abdominal pain.
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Osteomyelitis of the pubic symphysis after transrectal biopsies of the prostate

Urology (Gold Journal) In Press - Thu, 06/21/2018 - 00:00
We report a rare complication of MRI-targeted transrectal biopsy of the prostate. Patient developed severe pain in the right hip and groin area after which he was admitted to the hospital. There was an interval of two months between the onset of the symptoms and the diagnosis. Our report is the first to describe osteomyelitis of the pubic symphysis in combination with abscess formation in the surrounding soft tissues due to MRI-guided transrectal biopsy of the prostate.
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THE NATIONAL RESIDENT MATCHING PROGRAM CODE OF CONDUCT: WHAT IS THE PERCEIVED DEGREE OF COMPLIANCE DURING THE UROLOGY MATCH PROCESS?

Urology (Gold Journal) In Press - Thu, 06/21/2018 - 00:00
To assess the incidence of violations to the National Resident Matching Program (NRMP) Code of Conduct during the Urology Match.
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How can you stop a chronic UTI?

MedicalNewsToday - Wed, 06/20/2018 - 10:00
A urinary tract infection is a painful condition that has a variety of symptoms, including frequent urination accompanied by a burning feeling. There is a range of treatment options available for recurring urinary tract infections, including home remedies. Learn ways to prevent them, such as drinking plenty of water.
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What is penicillamine?

MedicalNewsToday - Wed, 06/20/2018 - 07:00
Penicillamine is a drug that is used to treat Wilson’s disease, rheumatoid arthritis, and kidney and bladder stones. It can have serious side effects, so it is important to follow the doctor’s instructions and to attend all follow-up appointments to monitor for any changes while taking this drug. Find out more.
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What is penicillamine?

MedicalNewsToday - Wed, 06/20/2018 - 07:00
Penicillamine is a drug that is used to treat Wilson’s disease, rheumatoid arthritis, and kidney and bladder stones. It can have serious side effects, so it is important to follow the doctor’s instructions and to attend all follow-up appointments to monitor for any changes while taking this drug. Find out more.
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Endoscopic Therapy for High Grade Vesicoureteral Reflux: First-Line Therapy or Too Good to be True?

In this issue of The Journal Friedmacher et al present their results on endoscopic injection of dextranomer/hyaluronic acid (Dx/HA) copolymer in children with grade IV to V vesicoureteral reflux (VUR).1 The results are impressive: 100% of the children were successfully treated and not a single postoperative complication (other than rapidly resolving gross hematuria in 2 children) occurred during a median followup of 8.5 years. Taken at face value, these results seem to imply that we should be pushing families toward endoscopic management.
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Anterior localization of prostate cancer suspicious MRI lesions in patients undergoing initial and repeat biopsy: Results from 1,161 patients undergoing MRI/ultrasound fusion-guided targeted biopsies

Based on findings from transrectal ultrasound guided (TRUS) biopsies series, standard sampling of the prostate targets the posterior/peripheral zone. However, a substantial proportion of PCa suspicious MRI PI-RADS ≥3 lesions is located in the anterior segment of the prostate, requiring a deeper placement and targeting of the biopsy needle.
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Intraoperative cyst rupture of partial nephrectomy for cystic renal masses: does it increase the risk of recurrence?

Our objective was to assess the prevalence of intraoperative cyst rupture (CR) and its impact on oncological outcomes.
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Reply by Authors

This was a small, nonrandomized, proof of concept study with a number of limitations. We agree that using 10 mg prednisone remains the standard of care for castration resistant prostate cancer. Most patients in IMAAGEN did report AEs, including these of special interest such as hypertension, fluid retention and hypokalemia. While AEs were manageable (mainly grade 1/2 with no patient discontinuing therapy due to mineralocorticoid excess or requiring prednisone dose escalation), using a lower dose of prednisone required careful monitoring and timely management.
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The Urology Match and Post-Interview Communication

Urology (Gold Journal) In Press - Wed, 06/20/2018 - 00:00
To understand the frequency and nature of post-interview communication as it relates to the rules and regulations of the American Urological Association (AUA) Urology Residency Matching, as well as the impact of such communication on the outcomes of the match.
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Li-Fraumeni Syndrome−Related Malignancies Involving the Genitourinary Tract: Review of a Single-Institution Experience

Urology (Gold Journal) In Press - Wed, 06/20/2018 - 00:00
To report a case of pelvic angiosarcoma in a 27-year-old man with Li-Fraumeni Syndrome (LFS) and evaluate the presentation and timeline of genitourinary (GU) tract involvement in LFS patients.
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High concentration of calcium promotes mineralization in NRK52E cells via inhibiting the expression of matrix Gla protein

Urology (Gold Journal) In Press - Wed, 06/20/2018 - 00:00
To address whether matrix Gla protein (MGP) can inhibit mineralization in normal rat kidney tubular cells (NRK-52E) under high concentration of calcium.
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Reply by Authors

We appreciate the comments on our study. There is clearly a road ahead and paths to tread to find the exact place of ultrasound SWE in the detection and phenotypic characterization of prostate cancer. There may be a place of combining this with MRI. However, publications in this area to date show promising results. What should be considered a discriminatory diagnostic cutoff level for benign and malignant lesions can be debated but there is some confidence that all studies in this area show differences in the relative stiffness estimates not only of cancer and noncancerous tissues but also of different Gleason grades (reference 12 in article).
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Editorial Comment

PCa detection remains a problem. Random TRUS biopsies have been the standard of care but they can often miss cancers and under grade the cancers that are identified. MRI has had success in identifying clinically significant PC and it may be helpful in active surveillance.1 SWE is a new technique that evaluates tissue stiffness.2 As most PCa is stiffer than normal prostate it can be detected by SWE and the stiffness appears to correlate with Gleason scores. However, benign prostatic nodules are also stiff, making evaluation of the central gland problematic with SWE.
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Editorial Comment

Imaging in localized prostate cancer is gaining importance. Specifically multiparametric MRI is frequently used for diagnosis, active surveillance, targeted biopsy and focal therapy. A major step in the acceptance and widespread use of MRI was the establishment of the standardized reporting system, PI-RADS® (Prostate Imaging-Reporting and Data System).1 Research on new techniques such as SWE should aim to establish comparable classification systems to catch up with MRI (reference 11 in article).
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