Urology News Feeds
Despite decades of practice there has been minimal improvement in the morbidity of RC. Importantly a strong association exists between complications and nutritional status but there is limited evidence to guide urologists on the choice and effectiveness of nutritional interventions. The current study demonstrates that an immune enhanced formula may attenuate the inflammatory response in patients who undergo RC, suggesting the potential for supplementation to improve RC outcomes. However, the small sample size limits the ability to determine whether supplementation translates into a clinically relevant benefit such as decreased complications.
The dissemination and implementation of evidence-based medicine across specialties is an ongoing challenge. That challenge is particularly evident in the field of perioperative nutrition. In 2011 Drover et al reported a systematic review of 35 randomized controlled trials of arginine supplemented immunonutrition in surgical patients, which identified a “substantial reduction in infection and shorter length of hospital stay.”1 Those studies were predominantly on gastrointestinal surgery and they included no urological studies.
Urologic Phenotype and Patterns of Care in Patients with Megacystis Microcolon Intestinal Hypoperistalsis Syndrome Presenting to a Major Pediatric Transplantation Center
To describe the phenotype, referral pattern, and trends of urologic management for children with megacystis microcolon intestinal hypoperistalsis syndrome.
Metabolomic Analysis of Overactive Bladder in Male Patients: Identification of Potential Metabolite Biomarkers
To identify metabolites that are associated with an overactive bladder (OAB) using metabolomics.
To investigate the clinical outcome of surgical treatment for long ureteral defect in children, we evaluated our experience of managing six children with the long defect utilizing laparoscopic ureteral reconstruction technique using Yang-Monti technique.
To estimate the change of discharge rate after cryptorchidism surgery between pre- and post-disaster in Japan. Cryptorchidism cannot be diagnosed before birth and is not a factor that would influence a woman's decision to seek an abortion. Therefore, this disease is considered suitable for assessing how the Great East Japan Earthquake and subsequent the Fukushima Daiichi nuclear accident (2011) influenced congenital diseases.
To evaluate the outcomes and factors affecting success of urethroplasty in patients with stricture recurrence after Urolume® urethral stent.
Volume 199, Number 4, Page 954, Abstract: In sentence 1 in Materials and Methods, the number of positive cores is 2 or fewer and the percentage of core involvement is 50% or less.
The authors analyze use of serial ultrasound and diuretic renography when following patients with unilateral SFU grade 3 to 4 hydronephrosis. The issue at hand is predicting which hydronephrotic kidneys have obstruction that may threaten development or function. The authors present a cautionary tale, concluding that 13.3% to 14.1% of kidneys with stable or decreased hydronephrosis on ultrasound demonstrate worsening function on diuretic renography. While this finding should give pause to the pediatric urologist who relies solely on ultrasound when following children with hydronephrosis, no easy solution is afforded.
The fate of the pediatric kidney exhibiting severe UTD is a concern for the pediatric urologist, the assumption being that the condition may be associated with a deleterious process that could affect renal function. The authors of this carefully designed study set out to determine if the changes observed through time on US correlate with functional findings on diuretic renography. The results of the study imply that they do not.
Ryan et al present the results of a single arm study of in nmCRPC using abiraterone plus prednisone. PSA responses were excellent but time to PSA progression was not as impressive as I would have anticipated, given that patients had lower PSA levels and less advanced disease than in mCRPC trials (reference 2 in article). Were these results due to the reduced dose of prednisone? In these patients at high risk is nmCRPC more aggressive than in patients with slowly progressing mCRPC?
The IMAAGEN trial investigators report data on treating a prospective cohort of men with nonmetastatic, castration resistant prostate cancer with abiraterone plus prednisone using a reduced dose of prednisone 5 mg daily. This dose change may seem trivial but using prednisone with abiraterone is important for toxicity reduction. Abiraterone depletes testosterone by inhibiting CYP17 conversion of androgen precursors to testosterone. However, these precursors are shunted into alternative enzymatic pathways.
The authors present a case series of cystic renal masses in children, for which correlation between imaging and histology was available. They show rather elegantly that pediatric urologists should be worried about any lesion with solid components (ie Bosniak 3 or 4) and can perhaps safely observe the majority of those without solid components (Bosniak 1 or 2). Furthermore, their data seem to lend support to the modified Bosniak classification based on Doppler ultrasound suggested by Wallis et al (reference 5 in article), which can in turn lead to avoiding radiation is many children being assessed and followed for a cystic renal lesion.
The authors report a single institution experience of renal cysts, correlating radiographic findings with pathology. They found that cysts with radiographic findings consistent with Bosniak 3 or 4 classification are more likely to have malignancy. As they note, this study does not mark the first time that pathological findings and radiological characteristics of the Bosniak classification, validated in adults, have been correlated in children. However, the prior study (reference 5 in article) had only 5 patients with radiology plus pathology results, and thus this latest series is substantially larger.
OS has been a topic of great interest in the study of varicocele associated infertility in the last 2 decades. Studies have confirmed the association of sperm DNA damage with OS and mitochondrial inactivity (reference 17 in article).1 In this quest sperm mitochondrial proteomic studies provide insight into the structural and functional irregularities which in turn may explain the apparent sperm dysfunction.
The authors have contributed to improve quality registration of care in men with localized prostate cancer by selecting a set of pertinent quality indicators from the literature, which is an essential first step in this process.
Women undergoing third line overactive bladder treatment demonstrate elevated thermal temporal summation
To determine if women with overactive bladder (OAB) requiring 3rd line therapy demonstrate greater central sensitization, indexed by temporal summation to heat pain stimuli, than those with OAB.
The aim of the present study was to report the outcomes of botulinum toxin A (BTX-A) intradetrusor injections in adult patients with spina bifida.
Long-term continence outcomes in men undergoing radical prostatectomy: A prospective 15 year longitudinal study
To examine the time dependent rates of urinary continence (UC) following open retropubic radical prostatectomy (ORRP).
The purpose of this guideline is to provide a clinical strategy for the diagnosis and treatment of erectile dysfunction.