Urology News Feeds
Polymorphisms of PTH (Parathyroid Hormone) Gene and Risk of Kidney Stone Disease: A Case-Control Study from West Bengal, India
To investigate the potential contribution of PTH (parathyroid hormone) gene polymorphisms in kidney stone disease (KSD), a global clinical problem impacting major burden on public health care system worldwide.
Whole Exome Sequencing of a Consanguineous Turkish Family Identifies a Mutation in GTF2H3 in Brothers with Spermatogenic Failure
In this case report we describe our investigation into the genetic cause of infertility due to idiopathic non-obstructive azoospermia in a consanguineous Turkish family. We extracted DNA from blood and applied whole exome sequencing (WES) on four infertile brothers in this family diagnosed with oligo- and azoospermia. Standard bioinformatics analysis pipelines were run including alignment to the reference genome, variant calling, and quality control filtering. Potentially pathogenic variants were identified and prioritized using genetic variant annotation software and public variant frequency databases, followed by validation with Sanger sequencing.
To review surgical outcomes in urinary undiversions and describe short and long-term complications.
To assess the performance of Ga-PSMA PET for positive lymph nodes on imaging after curatively intended radical prostatectomy.
Ureteroscopic Management of Large ≥ 2 cm Upper Tract Urothelial Carcinoma: A Comprehensive Twenty-three Year Experience
To evaluate the effectiveness of ureteroscopy (URS) with laser ablation as an alternative treatment for UTUC lesions larger than 2 cm. Traditionally, patients with large upper tract urothelial carcinoma (UTUC) are treated with radical nephroureterectomy (RNU). However, in patients with pre-existing renal disease, a solitary kidney, or those who decline RNU, management of UTUC may prove challenging
Predictors of Benign Uretero-enteric Anastomotic Strictures After Radical Cystectomy and Urinary Diversion
To determine predictors of symptomatic uretero-enteric anastomotic strictures (UAS) formation following radical cystectomy (RC) and urinary diversion (UD).
Predictive Analytics and Modeling Employing Machine Learning Technology: The Next Step in Data Sharing, Analysis and Individualized Counseling Explored with A Large, Prospective Prenatal Hydronephrosis Database
To explore the potential value of utilizing a commercially available cloud based machine learning platform to predict surgical intervention in infants with prenatal hydronephrosis (HN).
It is normal to feel a heaviness or pressure on the vagina or pelvis during pregnancy. The common causes of vaginal or pelvic pressure are different in the early and late trimesters but are not usually cause for concern. In this article, we look at common causes, when to see a doctor, and how to relieve symptoms.
Noncancer indications for simultaneous genitourinary and fecal diversion mainly include (1) complex enteral, fecal, and urinary fistulas; (2) refractory urinary and fecal incontinence from neurogenic bladder or bowel, or associated with complications from previous pelvic radiation, or from iatrogenic complication at the time of urologic, colorectal, or gynecologic surgery; (3) (promotion of healing of) complex decubitus ulcers affecting the coccygeal, perianal, perineal, and scrotal area. The natural disease progression of these catastrophic conditions is not well understood, and both urinary and fecal diversions are usually offered as the last therapeutic resort with curative or many times with palliative intent.
Patients requiring urinary and bowel diversion for non-oncologic indications constitute a poorly studied cohort in reconstructive urology. Scant literature exists to guide the colorectal surgeon or urologist on the impact of staged diversions as compared to simultaneous diversions. Oftentimes when faced with these patients, the historical wisdom is to perform staged diversions, as there is significant concern for increased morbidity, prolonged operative time, and delayed convalescence with after simultaneous “double” diversion.
Several years ago one of our fellows, Andrew Stec, who was a biomedical engineer, thought it would be helpful to obtain 3-D MRIs in all newborn exstrophy cases before and after closure. Our main interest at that time was distribution of the pelvic floor musculature before and after closure with and without pelvic osteotomy (reference 11 in article). Using this technology, along with new Brainlab technology intraoperative imaging, we have undertaken a U.S. Food and Drug Administration approved study that allows newborn and delayed closure under 3-D intraoperative guidance.
The authors present a landmark and novel finding in the female patient with classic bladder exstrophy. Although the study is a retrospective analysis with a small sample size, the data and knowledge gained add vast amounts of information regarding the anatomy of female patients with bladder exstrophy. As with most good studies, this one generates more questions than answers. The immediate clinical value of this article should make anybody who performs closure of female bladder exstrophy cautious when dissecting the pelvic floor.
We acknowledge that the missing information on serum levels of testosterone among the included TC survivors is a limitation of the current study. We recently performed a systematic review in which we found that radiotherapy, cisplatin based chemotherapy and more than 1 treatment line increase the risk of testosterone deficiency (total testosterone less than 10 nmol/l) compared to orchiectomy alone.1 However, to our knowledge it remains unknown whether mild biochemical testosterone deficiency causes symptoms such as decreased sexual desire and erectile dysfunction, and whether testosterone substitution should be offered to more than the approximately 5% of TC survivors reported in the current study.
With 2,260 patients (a 60% response rate) and an impressive 17-year followup this study is the largest cohort and longest followup ever reported on sexual function among testis cancer survivors. This robust analysis from Bandak et al demonstrated that while the majority of survivors maintained normal erectile function, patients with testis cancer who underwent adjuvant treatment after orchiectomy were at higher risk for erectile dysfunction than those who underwent orchiectomy alone. These significant findings should guide patient discussions regarding the long-term effects of testis cancer treatment.
The authors raise 3 important points. First, the familial incidence of hypospadias is underestimated and is more prevalent than previously reported (22.3%). Also, a positive family history is not correlated with type of hypospadias. Finally, genetic mutations are more frequently detected in familial cases.
A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Post-Finasteride Syndrome
To quantify reports made to the Food and Drug Administration Adverse Event Reporting System (FAERS), create a demographic of patient reports, and examine the cluster of symptoms to correlate consistency of post-finasteride syndrome (PFS) complaints. PFS is a provisional diagnosis encompassing a cluster of sexual, physical, and psychological/neurologic symptoms associated with 5-alpha reductase inhibitor (5ARI) use that emerge or continue after discontinuation of medication.
Reevaluating Warm Ischemia Time as a Predictor of Renal Function Outcomes After Robotic Partial Nephrectomy
: To explore whether variation of warm ischemia time (WIT) is associated with functional and perioperative outcomes following robotic partial nephrectomy (RPN).
A 12-Month Follow-up After a Single Intracavernous Injection of Autologous Adipose-derived Regenerative Cells in Patients with Erectile Dysfunction Following Radical Prostatectomy: An Open-label Phase I Clinical Trial
To explore safety in adipose-derived regenerative cells (ADRC) therapy, treating ED.
To test a novel visuospatial testing platform improve trainee ability to convert two-dimensional (2D) to three-dimensional (3D) space.
A 63-year-old female with known history of Lynch Syndrome with MSH2 gene deletion presented to the emergency department with left flank and epigastric pain worsening over one week. She had a three-year history of intermittent gross hematuria, with no masses or hydronephrosis on non-contrast abdominal and pelvic CT scan 2.5 years prior. Review of systems was otherwise negative. Patient reported previously negative evaluation with cystoscopy and repeat urinalysis for gross hematuria by outside urologist.