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Prodrome and Non-Prodrome Phenotypes of Bladder Pain Syndrome/Interstitial Cystitis

Urology (Gold Journal) In Press - Tue, 05/15/2018 - 00:00
To test the hypothesis that risk factors for BPS/IC in women differ between those with and without the BPS/IC prodrome.
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Author Reply: Assessing Time of Full Renal Recovery Following Minimally Invasive Partial Nephrectomy

Urology (Gold Journal) In Press - Tue, 05/15/2018 - 00:00
In adults, renal function recovery following partial nephrectomy plateaus, with no significant long-term recovery. Our study emphasizes the timing of this plateau, indicating that it occurs at 6-12 weeks, even earlier than previously suspected. Factors such as age and renal disease, though not investigated in our study, may impact the recovery trajectory. As highlighted, our results cannot be generalized to the pediatric population, where the evidence suggests a greater capacity for long-term renal function recovery.
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Reply by Authors

It is true that we grouped together all patients who underwent radical cystectomy due to bladder cancer regardless of their history. However, this approach resembles a real-life setting and thus is translatable to other urology departments. More importantly, patients with bladder cancer and ureteral stenting were compared not only to those with nephrostomy tube insertion, but also to the majority with no drainage at all. The proportion of patients with pTa/pTis/pT1 disease was similar between the no drainage group (23%) and the ureteral stent group (28%), and the same was true for history of intravesical instillations (21% vs 25%).
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Re: Development of a Surgical Safety Training Program and Checklist for Conversion during Robotic Partial Nephrectomies

F. Zattoni, A. Morlacco, F. Cattaneo, M. Soligo, L. Meggiato, D. Modonutti, C. Valotto, F. Dal Moro and F. Zattoni
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Re: Percutaneous Cryoablation of Renal Cell Carcinoma with Sinus Vein Involvement Based on Preprocedural Imaging

T. D. Atwell, A. N. Kurup, S. A. Boorjian, J. J. Schmitz, R. H. Thompson, B. C. Leibovich and G. D. Schmit
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This Month in Pediatric Urology

The increasing use of ultrasound in children, especially serial longitudinal imaging for hydronephrosis, has resulted in identification of more renal cysts in children. Many of these cystic lesions are seen in asymptomatic children, indicating a clear need for guidelines to help determine whether additional evaluation with computerized tomography (CT) is necessary and to define followup protocols for low risk cystic lesions. There have been few studies comparing radiographic and pathological findings to confirm the validity of the Bosniak classification for evaluating renal cysts in children.
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This Month in Adult Urology

Magnetic resonance imaging (MRI) fusion guided prostate biopsy is being used increasingly for the diagnosis of prostate cancer but important questions remain. Is a negative MRI study sufficient to exclude high risk disease without a biopsy? Can a template biopsy be eliminated and targeted biopsy alone be performed? Two studies in this issue of The Journal compare MRI directed transrectal prostate biopsy with perineal template biopsies. Mortezavi et al (page 000) from Switzerland found that 19.9% of clinically significant cancers would have been missed if only 3 targeted fusion biopsy samples were performed compared to a perineal template.
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Re: Stenting Prior to Cystectomy is an Independent Risk Factor for Upper Urinary Tract Recurrence

The authors report that in patients undergoing radical cystectomy preoperative drainage of the collecting system with ureteral stenting may be associated with an increased risk of upper tract recurrence when compared to nephrostomy. Upper tract drainage for hydronephrosis was performed in 114 of the 1,005 patients in this study (11%), including 53 (46%) by ureteral stenting and 61 (54%) by percutaneous nephrostomy. Recurrence was observed in 7 patients (13%) with stents, 24 patients (3%) with no drainage and no patient with a nephrostomy.
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New Evidence for the Benefit of PSA Screening: Data From 400,887 Kaiser Permanente Patients

Urology (Gold Journal) In Press - Mon, 05/14/2018 - 00:00
To investigate whether prostate cancer screening with PSA is beneficial in reducing prostate cancer mortality, and to determine optimal screening intervals and age groups to be screened.
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How to identify pitting edema

MedicalNewsToday - Sat, 05/12/2018 - 12:00
Edema refers to swelling caused by excess fluid. When swollen skin remains indented after being pressed, this is called pitting edema. It is most common in the legs, ankles, and feet. Several conditions and factors, such as pregnancy, can cause pitting edema. Learn how it is identified, treated, and prevented here.
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Certain antibiotics increase kidney stone risk

MedicalNewsToday - Sat, 05/12/2018 - 07:00
For the first time, researchers find a link between antibiotics and an increased risk of kidney stones. It seems that young people are most affected.
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Evaluation of an Aggressive Prostate Biopsy Strategy in Men Younger than 50 years of Age

Longitudinal cohort studies and guidelines demonstrate that PSA ≥1 ng/mL in younger patients confer an increased risk of delayed prostate cancer (PC) death. In our institution we have used an aggressive biopsy strategy among younger patients with PSA of>1 ng/ml. Our objective was to determine the proportion of detected cancer and specifically, clinical significant cancer, with this strategy.
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Prostate-specific antigen density as a predictor of clinically significant prostate cancer when the PSA level is in the diagnostic “grey-zone”: Defining the optimum cut-point stratified by race and body mass index

To assess the predictive value of prostate-specific antigen density (PSAD) to detect clinically significant prostate cancer (prostate cancer grade group (GrGp) ≥2) in a series of men undergoing prostate biopsy with PSA 4-10 ng/mL. We sought to define an optimum cut-point for PSAD and assess how race and body mass index (BMI) affects PSAD performance.
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Race- and Sex-Related Differences in Nephrolithiasis Risk among Blacks and Whites in the Southern Community Cohort Study

Urology (Gold Journal) In Press - Thu, 05/10/2018 - 00:00
ObjectivesTo investigate race-sex associations with risk among whites and blacks in the southeastern United States. The relationship between race, sex, and kidney stone risk is poorly understoodMethodsParticipants were 42,136 black and white adults enrolled in the Southern Community Cohort Study between 2002-2009, with no history of kidney stones and receiving Medicare or Medicaid services. Incident kidney stone diagnoses through December 2014 were determined via linkage with Centers for Medicare and Medicaid Services research files.
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Outcomes of Conservative Management of Asymptomatic Live Donor Kidney Stones

Urology (Gold Journal) In Press - Thu, 05/10/2018 - 00:00
To evaluate the long-term outcomes of asymptomatic stones ≤4 mm which are left in situ during renal transplantation (RT).
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High-potassium foods to avoid with kidney disease

MedicalNewsToday - Wed, 05/09/2018 - 07:00
People with chronic kidney disease need to avoid eating potassium-rich foods. Damaged kidneys cannot process potassium properly, which can then build up in the blood and cause weakness, fatigue, and tingling. In this article, learn which high-potassium foods to avoid with kidney disease and what to replace them with.
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Reply by Authors

The comments highlight the importance of this work and the need for additional confirmatory trials. Although our initial pilot study suggests an improvement in infectious complications in patients who received SIM (reference 22 in article), a larger study is needed to confirm these results. Accordingly a multicenter trial run through the SWOG (Southwest Oncology Group) known as S1600 or SIMmune (A Randomized Phase III Double-Blind Clinical Trial Evaluating the Effect of Immune-Enhancing Nutrition on Radical Cystectomy Outcomes) is set to launch in 2018.
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