Urology News Feeds

Re: Genetic Determinants of Cisplatin Resistance in Patients with Advanced Germ Cell Tumors

A. Bagrodia, B. H. Lee, W. Lee, E. K. Cha, J. P. Sfakianos, G. Iyer, E. J. Pietzak, S. P. Gao, E. C. Zabor, I. Ostrovnaya, S. D. Kaffenberger, A. Syed, M. E. Arcila, R. S. Chaganti, R. Kundra, J. Eng, J. Hreiki, V. Vacic, K. Arora, D. M. Oschwald, M. F. Berger, D. F. Bajorin, M. S. Bains, N. Schultz, V. E. Reuter, J. Sheinfeld, G. J. Bosl, H. A. Al-Ahmadie, D. B. Solit and D. R. Feldman
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Re: Effectiveness of Adjuvant Chemotherapy after Radical Nephroureterectomy for Locally Advanced and/or Positive Regional Lymph Node Upper Tract Urothelial Carcinoma

T. Seisen, R. E. Krasnow, J. Bellmunt, M. Rouprêt, J. J. Leow, S. R. Lipsitz, M. W. Vetterlein, M. A. Preston, N. Hanna, A. S. Kibel, M. Sun, T. K. Choueiri, Q. D. Trinh and S. L. Chang
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Re: Continuous Normothermic Ex Vivo Kidney Perfusion is Superior to Brief Normothermic Perfusion following Static Cold Storage in Donation after Circulatory Death Pig Kidney Transplantation

J. M. Kaths, J. Y. Cen, Y. M. Chun, J. Echeverri, I. Linares, S. Ganesh, P. Yip, R. John, D. Bagli, I. Mucsi, A. Ghanekar, D. R. Grant, L. A. Robinson and M. Selzner
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Re: Variation in the Use of Open Pyeloplasty, Minimally Invasive Pyeloplasty, and Endopyelotomy for the Treatment of Ureteropelvic Junction Obstruction in Adults

B. L. Jacobs, J. C. Lai, R. Seelam, J. M. Hanley, J. S. Wolf, Jr., B. K. Hollenbeck, J. M. Hollingsworth, A. W. Dick, C. M. Setodji and C. S. Saigal
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Reply by Authors

The comment states that our “findings are interesting and have immense clinical application.” We would like to provide clarification about some of the concerns in the comment. In our work we did in fact explore the role of salt and protein consumption. We had previously examined salt and protein consumption individually but chose the DASH score because it already incorporates them. We also attempted to define kidney stone type in a large validation study (reference 7 in article). We reviewed medical records in a subgroup of participants who reported a kidney stone.
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Editorial Comment

Using data on 3 large cohorts Ferraro et al report that several modifiable risk factors are associated with a lower risk of incident kidney stones, including fluid intake, BMI, DASH diet, dietary calcium intake and sugar sweetened beverages. These findings are interesting and have immense clinical application.
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Author Reply

Urology (Gold Journal) In Press - Mon, 07/03/2017 - 00:00
The above commentary nicely crystallizes the basic pathophysiological tenants of stricture formation and explains how increasing age is theorized to place patients at risk of poor outcomes. Our collective experience demonstrates that patients are often indiscriminately subjected to age bias when counseled on the various treatment options for urethral stricture disease. There appears to be a decidedly lower threshold to employ repetitive, even scheduled endoscopic treatments for older patients in an effort to avoid “major surgery.” Heyns et al analyzed pre-referral stricture management for patients who eventually underwent urethroplasty, noting that patients with 5-6 endoscopic interventions before referral had an average age of 60.2 years vs 46.6 years in those receiving 1-2 interventions.
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The Impact of Age on Urethroplasty Success

Urology (Gold Journal) In Press - Mon, 07/03/2017 - 00:00
Urethroplasty is the definitive surgical treatment for strictures with a success rate of 85-90% for simple procedures and about 80% for extremely complex repairs.1
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Re: Surgical Options for the Enlarged, Obstructing, Benign Prostate

In this editorial reviewing surgical options for benign prostatic hyperplasia Parsons concludes that holmium laser enucleation of the prostate (HoLEP) and robot-assisted simple prostatectomy (RASP) for large volume glands result in equivalent outcomes. We have concerns with use of the term “equivalent” in the absence of level 1 evidence supporting this assertion.
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Mixed results on effectiveness of acupuncture to treat stress urinary incontinence, infertility

MedicalNewsToday - Thu, 06/29/2017 - 02:00
Electroacupuncture improved stress urinary incontinence - that's when a woman can experience an involuntary loss of urine such as when sneezing or coughing - but acupuncture did not increase the...
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Sexual Satisfaction: an Opportunity to Explore Overall Health in Men

Urology (Gold Journal) In Press - Thu, 06/29/2017 - 00:00
The primary aim was to evaluate the use of sexual dissatisfaction as a marker of poor overall health. Secondary objectives were to assess the effect of age on this measure and the utility of the Brief Sexual Symptom Checklist (BSSC) for general practitioners (GPs) and patients.
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Twitter Activity Associated with US News and World Report Reputation Scores for Urology Departments

Urology (Gold Journal) In Press - Thu, 06/29/2017 - 00:00
To analyze the association between US urology department Twitter presence and U.S. News and World Report (USNWR) reputation scores, to examine the content, informational value, and intended audience of these platforms, and to identify objectives for Twitter use.
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Independent Validation of the American Joint Committee on Cancer 8th Edition Prostate Cancer Staging Classification

We sought to independently validate the American Joint Committee on Cancer (AJCC) 8th edition prostate cancer (PCa) staging classification, which includes the elimination of pT2 subcategories and the reclassification of patients with PSA≥20ng/ml and Gleason Grade Group (GG)-5 as Stage Group III-A and III-C, respectively.
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Reply by Authors

The comment indicates that laser energy for focal therapy belongs in the MRI suite, ie in bore. However, FLA out of bore performed in clinic can yield an ablation zone indistinguishable from that of in bore FLA (see figure). The key conclusion of our phase I trial is that FLA can be performed safely and satisfactorily by a urologist in a clinic setting out of bore using MRI-US fusion for guidance. Nonrigid registration was used to match MRI to ultrasound and the cancer location was targeted using the same platform for diagnosis and treatment.
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Editorial Comment

Targeted lesion based, zonal based and hemiablation strategies have been proposed for focal therapy. It is intuitive that the smaller the ablated volume to achieve cancer control, the less the potential of side effects from treatment. Laser ablation is precise and allows for targeted ablation up to 2 cm in diameter. Larger ablations necessitate an increase in insertions and time (reference 8 in article). Therefore, laser energy is ideally suited for targeted lesion based ablation and it relies on accurate imaging provided by MRI and biopsy information to guide therapy.
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