Urology News Feeds

Diagnostic accuracy of a rapid biparametric MRI protocol for detection of histologically proven prostate cancer

Urology (Gold Journal) In Press - Fri, 09/07/2018 - 00:00
Objective: To evaluate the performance of a rapid, low cost, non-contrast MRI examination as a secondary screening tool in detection of clinically significant prostate cancer.Methods: In this prospective single institution study 129 patients with elevated PSA levels or abnormal digital rectal examination findings underwent MRI with an abbreviated biparamatric MRI protocol consisting of high resolution axial T2- and diffusion weighted images. Index lesions were classified according to PI-RADS v2.0.
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Perioperative Troponin is a Predictor of Both Short- and Intermediate-Term Mortality Among Patients Undergoing Major Urologic Surgery

Urology (Gold Journal) In Press - Fri, 09/07/2018 - 00:00
To determine whether positive troponin is a predictor of intermediate and long-term mortality in patients undergoing major urologic surgeries at our institution.
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Re: Clomiphene Citrate and Human Chorionic Gonadotropin Are Both Effective in Restoring Testosterone in Hypogonadism: A Short-Course Randomized Study

M. Habous, S. Giona, A. Tealab, M. Aziz, B. Williamson, M. Nassar, Z. Abdelrahman, A. Remeah, M. Abdelkader, S. Binsaleh and G. Muir
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Re: An Analysis of Online Content Related to Testosterone Supplementation

E. Sehn, C. Mozak, N. Yuksel and C. A. Sadowski
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Re: A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Post-Finasteride Syndrome

W. R. Baas, M. J. Butcher, A. Lwin, B. Holland, M. Herberts, J. Clemons, K. Delfino, S. Althof, T. S. Kohler and K. T. McVary
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Re: Cardiovascular Safety of Phosphodiesterase Type 5 Inhibitors after Nearly 2 Decades on the Market

R. A. Kloner, I. Goldstein, M. G. Kirby, J. D. Parker and R. Sadovsky
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Re: Impact of Adjuvant Radiation on Artificial Urinary Sphincter Durability in Postprostatectomy Patients

A. Srivastava, G. A. Joice, H. D. Patel, M. G. Manka, N. A. Sopko and E. J. Wright
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Re: Hypoandrogenism is Prevalent in Males with Urethral Stricture Disease and is Associated with Longer Strictures

J. Spencer, J. Mahon, M. Daugherty, L. Chang-Kit, S. Blakely, A. McCullough, T. Byler and D. Nikolavsky
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Re: Luteolin Attenuates Wnt Signaling via Upregulation of FZD6 to Suppress Prostate Cancer Stemness Revealed by Comparative Proteomics

K. Han, T. Lang, Z. Zhang, Y. Zhang, Y. Sun, Z. Shen, R. W. Beuerman, L. Zhou and D. Min
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Re: Systemic Surfaceome Profiling Identifies Target Antigens for Immune-Based Therapy in Subtypes of Advanced Prostate Cancer

J. K. Lee, N. J. Bangayan, T. Chai, B. A. Smith, T. E. Pariva, S. Yun, A. Vashisht, Q. Zhang, J. W. Park, E. Corey, J. Huang, T. G. Graeber, J. Wohlschlegel and O. N. Witte
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Re: SPAG5 Promotes Proliferation and Suppresses Apoptosis in Bladder Urothelial Carcinoma by Upregulating Wnt3 via Activating the AKT/mTOR Pathway and Predicts Poorer Survival

J. Y. Liu, Q. H. Zeng, P. G. Cao, D. Xie, F. Yang, L. Y. He, Y. B. Dai, J. J. Li, X. M. Liu, H. L. Zeng, X. J. Fan, L. Liu, Y. X. Zhu, L. Gong, Y. Cheng, J. D. Zhou, J. Hu, H. Bo, Z. Z. Xu and K. Cao
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This Month in Pediatric Urology

Although technical refinements in hypospadias surgery have led to satisfactory functional and cosmetic results in distal hypospadias, surgical outcomes for proximal hypospadias continue to be challenging. Many patients still require multiple procedures throughout life and experience issues associated with a shorter phallus. While surgical outcomes have been the focus of most studies, few studies have been published on the psychological and sexual functional outcomes for adolescents with proximal hypospadias.
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Editorial Comment

The authors present an interesting study on the long-term functional impact of acute kidney injury after partial nephrectomy. For this purpose the investigators selected a cohort of patients with a solitary kidney who underwent partial nephrectomy. The serum creatinine change following surgery was corrected for the amount of tissue removed, which greatly strengthens the results and conclusions obtained.
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Reply by Authors

The discovery of the frequently encountered, sporadic, complex renal cyst presents a unique problem. It is important to remember that radiological characterization is dynamic and not a pathological diagnosis. While the Bosniak classification has stood the test of time, it is fraught with interobserver variability and a 50-50 likelihood of malignancy in Bosniak 3 lesions, and it has inadvertently resulted in overzealous repeat radiological imaging.
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Editorial Comment

When managing renal cysts, conventional teaching suggests that Bosniak 1/2 cysts can be observed while more complex Bosniak 3/4 lesions warrant surgical resection. The current study by Pruthi et al bolsters the argument that this management paradigm is overly simplistic and likely results in overtreatment of many clinically indolent lesions.
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Reply by Authors

We agree that AUS implantation is a “tricky risky” surgery with a high rate of complications in primary placement and this study looked at reinsertion after previous erosion. As this study shows even high volume surgeons at multiple sites have trouble with this patient group.
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Editorial Comment

In the United States AUS surgery is done infrequently (6,000 per year) by few urologists (15%), probably because of its high complication rate. These authors analyzed the complications of high volume surgeons following reinsertion after previous erosion.
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Comparative Efficacy of Laparoscopic Versus Robotic Adrenalectomy for Adrenal Malignancy

Urology (Gold Journal) In Press - Thu, 09/06/2018 - 00:00
To evaluate whether the technical advantages of robotic-assisted surgery over standard laparoscopy, which are well established for complex renal surgery, lead to variable surgical outcomes between laparoscopic adrenalectomy (LA) and robotic adrenalectomy (RA).
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