Urology News Feeds

Re: MicroRNA-141 Suppresses Prostate Cancer Stem Cells and Metastasis by Targeting a Cohort of Pro-Metastasis Genes

C. Liu, R. Liu, D. Zhang, Q. Deng, B. Liu, H. P. Chao, K. Rycaj, Y. Takata, K. Lin, Y. Lu, Y. Zhong, J. Krolewski, J. Shen and D. G. Tang
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Re: AKT-Mediated Stabilization of Histone Methyltransferase WHSC1 Promotes Prostate Cancer Metastasis

N. Li, W. Xue, H. Yuan, B. Dong, Y. Ding, Y. Liu, M. Jiang, S. Kan, T. Sun, J. Ren, Q. Pan, X. Li, P. Zhang, G. Hu, Y. Wang, X. Wang, Q. Li and J. Qin
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Re: Effect of Longer-Interval vs Standard Dosing of Zoledronic Acid on Skeletal Events in Patients with Bone Metastases: A Randomized Clinical Trial

A. L. Himelstein, J. C. Foster, J. L. Khatcheressian, J. D. Roberts, D. K. Seisler, P. J. Novotny, R. Qin, R. S. Go, S. S. Grubbs, T. O’Connor, M. R. Velasco, Jr., D. Weckstein, A. O’Mara, C. L. Loprinzi and C. L. Shapiro
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Re: Outcome of Men with Relapse after Adjuvant Carboplatin for Clinical Stage I Seminoma

S. Fischer, T. Tandstad, M. Wheater, E. Porfiri, A. Fléchon, J. Aparicio, D. Klingbiel, B. Skrbinc, U. Basso, J. Shamash, A. Lorch, K. P. Dieckmann, G. Cohn-Cedermark, O. Ståhl, C. Chau, E. Arriola, K. Marti, P. Hutton, B. Laguerre, P. Maroto, J. Beyer and S. Gillessen
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Re: Testicular Seminoma Clinical Stage 1: Treatment Outcome on a Routine Care Level

K. P. Dieckmann, I. Dralle-Filiz, C. Matthies, J. Heinzelbecker, J. Bedke, J. Ellinger, P. Anheuser, R. Souchon and U. Pichlmeier; German Testicular Cancer Study Group
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Re: New Strategies in Bladder Cancer: A Second Coming for Immunotherapy

A. Ghasemzadeh, T. J. Bivalacqua, N. M. Hahn and C. G. Drake
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This Month in Pediatric Urology

The 3 articles in this issue of The Journal of Urology address hypospadias, nocturnal enuresis and testicular torsion, which are representative of the most commonly identified topics in pediatric urology. Hypospadias is a congenital anomaly of anatomy, nocturnal enuresis is difficulty achieving a developmental milestone and testicular torsion is a common emergency for which an accurate prompt diagnosis is essential.
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This Month in Adult Urology

Women who must have surgery to remove a synthetic sub urethral sling would have obvious disappointment in the failure of the first option and also face a difficult decision about what to do next. Singla et al (page 000) from Dallas, Texas report the encouraging results in 27 of 72 women who experienced no subjective leakage even after sling removal.1 Of those who reported leakage success was achieved with a minimally invasive approach in more than 75%. Not surprisingly, none opted to have another sling placed.
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Editorial Comment

A significant strength of this study is the large number of surgeons and patients in whom the HoLEP learning curve was evaluated. There are no real surprises, in that with increasing surgeon case experience there was an improvement in technical performance parameters as well as a decrease in complications.
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Editorial Comment

There are many reports reviewing surgical experience with HoLEP. Many have focused on the learning experience since the procedure has a reputation of being difficult to master with a high learning curve. As a result multicenter and multisurgeon studies are rare.
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Editorial Comment

Benign prostatic hyperplasia publications are dominated by reports on treatment efficacy and new technologic gizmos or medications. While these treatments may eventually offer a reduction in treatment costs, they are inherently expensive during the initial introduction and use. As BPH is a ubiquitous disease with a significant cost burden, the ability to follow patients in a cost sensitive schema may become more important, especially as fee for service disappears and capitated contracts become the norm.
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Editorial Comment

The authors mention the relatively low sensitivity of PI-RADSv2 categories 3 and 4 for significant cancer. Inclusion criteria and screening patterns may have affected the disease prevalence and quite possibly the biopsy yield irrespective of imaging findings, given ethnic and regional changes in cancer.1 Despite this, PI-RADSv2 has shown some promising results in other studies with up to 91% sensitivity and 81% specificity for category 4-5.2 Understanding how the pretest likelihood affects the overall yield will be an important aspect of the next iteration of PI-RADS.
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Female genital sores: Causes and diagnosis

MedicalNewsToday - Tue, 06/13/2017 - 11:00
What are female genital sores and what are the main causes? How might a sore be prevented, how are they diagnosed, and what is the outlook?
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Long-Term Efficacy of Young-Dees Bladder Neck Reconstruction: Role of the Associated Bladder Neck Injection for the Treatment of Children with Urinary Incontinence

Urology (Gold Journal) In Press - Tue, 06/13/2017 - 00:00
To compare the long-term efficacy of Young-Dees bladder neck reconstruction (YDBNR) alone versus YDBNR plus BNI in patients with urinary incontinence caused by urethral sphincter insufficiency.
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Stones First! a Gas Pyelo-Nephroscopy Strategy for Laparoscopic Pyeloplasty and Renal Stone Extraction

Urology (Gold Journal) In Press - Tue, 06/13/2017 - 00:00
To report our experience on gas endoscopy as the first step of pelvi-ureteric junction (PUJ) obstruction repair when complicated by nephrolithiasis.
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Prostate Mass as a First Manifestation of Myeloid Sarcoma in a Patient with an Occult Acute Myeloid Leukemia - a Case Report

Urology (Gold Journal) In Press - Tue, 06/13/2017 - 00:00
Myeloid sarcoma (MS) with either primary or secondary prostate involvement is extremely rare. Its diagnostic is particularly challenging when prostate lesion precedes the systemic manifestation of a myeloproliferative disorder. We report such a case in a 44-year-old man with a prostate mass as a first manifestation of myeloid sarcoma associated with acute myeloid leukemia (AML). The diagnosis of lymphoproliferative disorder was suspected in the prostate magnetic resonance imaging (MRI) and MS was confirmed after transrectal ultrasound-guided prostate core biopsy.
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Author Reply

Urology (Gold Journal) In Press - Tue, 06/13/2017 - 00:00
We appreciate the editorial comments as they highlight aspects of resident training, sleep, and call schedules that our study only begins to address.
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Editorial Comment

Urology (Gold Journal) In Press - Tue, 06/13/2017 - 00:00
Morhardt et al. presented a fascinating paper demonstrating that resident physicians could use a commercially available activity monitoring device, a Fitbit, to track sleep quality while on call and post call. This represents a novel use of technology in a real world setting. The effect of fatigue and sleep deprivation on cognitive and physical performance has been a topic of research for years, and concerning outcomes have been observed. The majority of studies have focused on resident performance but the effect of sleep interruption on attending physicians has also come under scrutiny.
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