Urology News Feeds

Natural history and Predictors of Parastomal Hernia after Robot-Assisted Radical Cystectomy and Ileal Conduit Urinary Diversion

We investigated the prevalence, variables associated with parastomal hernia (PSH), and its outcomes of after robot-assisted radical cystectomy (RARC) and ileal conduit (IC) for bladder cancer.
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Reply by Authors

The low through-plane resolution of whole mount slides can cause overestimation of tumor volume, especially when calculated as “the sum of tumor areas at different levels multiplied by the section thickness.”2 This method extrudes outward even at the far apex and base (part A of figure). By comparison, we interpolated between contours and tapered the extrusion at the far apex and base (part B of figure), refining and decreasing the volume estimates.
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Re: Magnetic Resonance Imaging Underestimation of Prostate Cancer Geometry: Use of Patient Specific Molds to Correlate Images with Whole Mount Pathology

Priester et al add to the message of others underlining that magnetic resonance imaging (MRI) underestimates the size and extent of prostate tumors. Indeed, all macroscopic estimation of any tumor will underestimate histological tumor extent, which, after all, is why we apply a margin to the excision of any solid tumor. The data presented are concordant with data previously reported in The Journal that emphasize the importance of accurate registration between the in vivo and ex vivo excised prostate.
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Complete Penile Disassembly for Repair of Epispadias Causes Erectile Tissue Alteration Through TGF-Β1 Overexpression in Rabbit Model

Urology (Gold Journal) In Press - Wed, 09/06/2017 - 05:00
To investigate corporal tissue viability and changes in endothelial content following current techniques used for epispadias repair in animal model
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Female Outlet Obstruction after Anti-Incontinence Surgery

Urology (Gold Journal) In Press - Wed, 09/06/2017 - 05:00
Numerous surgical options are available for management of stress urinary incontinence in women, including urethral bulking agents, pubo-vaginal slings, retropubic bladder neck suspensions, mid-urethral slings, and even artificial urinary sphincters. We discuss the incidence, etiology, diagnosis, evaluation, and management of bladder outlet obstruction (BOO) after anti-incontinence surgery in females. This problem presents with a wide range of symptoms. Urodynamic evaluation is not always diagnostic, but can be helpful.
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Incidence of Clinically Significant Prostate Cancer after a Diagnosis of Atypical Small Acinar Proliferation (ASAP), High Grade Prostatic Intraepithelial Neoplasia (HGPIN), or Benign Tissue

Urology (Gold Journal) In Press - Wed, 09/06/2017 - 05:00
ObjectiveTo assess the incidence of clinically significant and insignificant prostate cancer after an initial biopsy that revealed either atypical small acinar proliferation (ASAP), high grade prostatic intraepithelial neoplasia (HGPIN), or benign tissue.MethodsWe retrospectively identified patients diagnosed with ASAP, HGPIN or benign tissue who had a repeat prostate biopsy within one year of diagnosis during 1987-2015. We compared the incidence of any prostate cancer and clinically significant prostate cancer (based on Gleason score, prostate-specific antigen (PSA), number of positive cores and core volume) for each diagnostic group.
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The Role of Gut Microbiome in the Pathogenesis of Prostate Cancer: a Prospective, Pilot Study

Urology (Gold Journal) In Press - Wed, 09/06/2017 - 05:00
To elucidate potential biomarkers or mechanistic principles involved with the gut microbiota and its impact on prostate cancer pathogenesis.
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Primary Mediastinal Pure Seminomatous Germ Cell Tumor (Germinoma) as a Rare Cause of Precocious Puberty in a 9 Year-Old Patient

Urology (Gold Journal) In Press - Wed, 09/06/2017 - 05:00
Less than 5-7% of germ cell tumors (GCTs) are extragonadal, being the central nervous system (CNS) the most common location in children, followed by retroperitoneum and mediastinum. Only 10% of mediastinal tumors are malignant and one third of these are pure seminomas (germinomas). We report the case of a 9 year-old boy with development of secondary sexual characteristics. Beta human chorionic gonadotropin (B-hCG) was elevated and a mediastinal mass was found. Final histology showed a pure seminomatous germ cell tumor (SGCT).
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Researchers discover MRI can measure kidney scarring and predict future kidney function

MedicalNewsToday - Tue, 09/05/2017 - 07:00
Researchers from St. Michael's Hospital have made what are believed to be two world first discoveries: an MRI can measure kidney damage and can predict future kidney function within one year while...
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Researchers discover MRI can measure kidney scarring and predict future kidney function

MedicalNewsToday - Tue, 09/05/2017 - 07:00
Researchers from St. Michael's Hospital have made what are believed to be two world first discoveries: an MRI can measure kidney damage and can predict future kidney function within one year while...
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Successful Treatment of Residual Curvature in Peyronie's Disease in Men Previously Treated with Intralesional Collagenase Clostridium Histolyticum

Urology (Gold Journal) In Press - Tue, 09/05/2017 - 05:00
To determine the success and feasibility of surgically correcting residual curvature after intralesional collagenase Clostridium histolyticum (CCH) for the treatment of Peyronie's disease.
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This Month in Pediatric Urology

Children with neuropathic bladder require careful monitoring throughout childhood and adolescence to avoid chronic renal complications associated with increased bladder pressure. Evaluation has historically involved use of serial renal ultrasonography and periodic urodynamic studies. Although there has been a significant reduction in long-term renal injury with aggressive surveillance, urodynamic evaluations are still costly and bladder monitoring occurs in an artificial setting in the office with rapid bladder filling.
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Personalized Treatment of Vesicoureteral Reflux: Where Are we Now?

In the Japanese tale “Rashomon,” popularized in the classic 1950 film directed by Akira Kurosawa,1 several observers emerge from a forest having seen the same event. All describe versions of the event that are very unlike each other. Similarly witnesses of crime scenes can contradict each other, each one convinced that he or she saw what actually happened.
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Editorial Comment

Teloken et al report the effect of the zone of origin of prostate cancer on biochemical failure in a large series of radical prostatectomies. They found that for high risk prostate cancer an origin in the transition zone imparted a better prognosis concerning the chance of biochemical failure.
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Editorial Comment

In this large retrospective review of 7,051 patients treated with radical prostatectomy the authors analyzed the effect of tumor origin on clinicopathological outcomes. They incorporated zonal origin into a high grade nomogram predicting freedom from biochemical recurrence at 3 years. The results of this study support previous studies in which transition zone prostate cancers were associated with favorable pathological features and better recurrence-free survival (reference 4 in article).
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Secondary Urethral Malignancies Following Prostate Brachytherapy

Urology (Gold Journal) In Press - Mon, 09/04/2017 - 05:00
To understand urethral secondary malignancies among patients treated with brachytherapy (BRT) for primary prostate cancer.
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Ureteroscopic Urinary Stone Treatment among Patients with Renal Anomalies: Patient Characteristics and Treatment Outcomes

Urology (Gold Journal) In Press - Mon, 09/04/2017 - 05:00
To evaluate patients' characteristics, surgical procedure data, and outcomes of URS stone treatment in patients with a horseshoe kidney (HSK), ectopic kidney (EK), and malrotated kidney (MK).
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Safety and Effectiveness of Holmium Laser Enucleation of the Prostate Using a Low-Power Laser

Urology (Gold Journal) In Press - Mon, 09/04/2017 - 05:00
To assess the safety and effectiveness of holmium laser enucleation of the prostate (HoLEP) using a low-power 30 W holmium laser with an en-bloc enucleation technique.
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Prostate Cancer in Transgender Women: Incidence, Etiopathogenesis, and Management Challenges

Urology (Gold Journal) In Press - Mon, 09/04/2017 - 05:00
To critically analyze the available evidence regarding the incidence, etiopathogenesis, and management of CaP in this specific subset of patients. In addition, this manuscript aims to present a recent case report of a transgender woman with a unique presentation at the author's institution.
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The Efficacy of Tadalafil Daily Versus on Demand in the Treatment of Erectile Dysfunction: a Systematic Review and Meta-Analysis

Urology (Gold Journal) In Press - Mon, 09/04/2017 - 05:00
We present a review comparing the use of tadalafil daily versus on-demand for erectile dysfunction. We examined randomized controlled trials and observational studies that examined the use of tadalafil for at least 8 weeks of follow-up with the primary outcome of International Index for Erectile Dysfunction- Erectile Function domain (IIEF-EF). Eight studies were identified that examined the desired dosing regimens. Of these, six studies included the primary endpoint of twelve weeks. Those patients taking tadalafil daily for 12 weeks scored on average 1.82 points higher in IIEF-EF scores, although the difference may not be clinically significant (see Figure 1).
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