Urology News Feeds

Re: Phase III, Double-Blind, Randomized Trial That Compared Maintenance Lapatinib versus Placebo after First-Line Chemotherapy in Patients with Human Epidermal Growth Factor Receptor 1/2-Positive Metastatic Bladder Cancer

T. Powles, R. A. Huddart, T. Elliott, S. J. Sarker, C. Ackerman, R. Jones, S. Hussain, S. Crabb, S. Jagdev, J. Chester, S. Hilman, M. Beresford, G. Macdonald, S. Santhanam, J. A. Frew, A. Stockdale, S. Hughes, D. Berney and S. Chowdhury
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Re: A CCR4 Antagonist Reverses the Tumor-Promoting Microenvironment of Renal Cancer

C. Berlato, M. N. Khan, T. Schioppa, R. Thompson, E. Maniati, A. Montfort, M. Jangani, M. Canosa, H. Kulbe, U. B. Hagemann, A. R. Duncan, L. Fletcher, R. W. Wilkinson, T. Powles, S. A. Quezada and F. R. Balkwill
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Re: Enterobacteria Secrete an Inhibitor of Pseudomonas Virulence during Clinical Bacteriuria

S. I. Ohlemacher, D. E. Giblin, D. A. d’Avignon, A. E. Stapleton, B. W. Trautner and J. P. Henderson
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Re: Prostate Cancer-Associated SPOP Mutations Confer Resistance to BET Inhibitors through Stabilization of BRD4

X. Dai, W. Gan, X. Li, S. Wang, W. Zhang, L. Huang, S. Liu, Q. Zhong, J. Guo, J. Zhang, T. Chen, K. Shimizu, F. Beca, M. Blattner, D. Vasudevan, D. L. Buckley, J. Qi, L. Buser, P. Liu, H. Inuzuka, A. H. Beck, L. Wang, P. J. Wild, L. A. Garraway, M. A. Rubin, C. E. Barbieri, K. K. Wong, S. K. Muthuswamy, J. Huang, Y. Chen, J. E. Bradner and W. Wei
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This Month in Adult Urology

Renal colic from ureteral calculus is almost by definition intermittent in intensity. Episodes of severe pain may alternate with periods of complete pain relief, sometimes making it difficult to know if spontaneous stone passage has occurred. In this retrospective study Hernandez et al (page 000) from Boston, Massachusetts evaluated patients with a known ureteral stone who were pain-free for at least 72 hours, of whom 26% had a persistent stone despite being without pain.1 The authors conclude that followup imaging is required to ensure stone passage even if pain has resolved to prevent silent long-term obstruction of the kidney.
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Reply by Authors

We agree with the Editorial Comment. Indeed, this report is not meant to discourage consideration of active surveillance as a first line strategy for men with low risk disease. Nonetheless, it remains notable that the 15-year rates of metastatic disease and prostate cancer death observed at our institution (0.6% and 0.1%, respectively) were achieved in a low risk population in which only 8% of men harbored more than 4 positive biopsy cores. This finding acknowledges the truly limited spectrum of low risk disease represented in our AS cohort and emphasizes how substantially our cohort differs from the overall low risk population.
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Editorial Comment

The Johns Hopkins AS series is enriched with patients with low volume disease who are at very low risk. The authors state that their series does not represent the overall low risk population and recommend against referencing their 15-year oncologic outcomes to support recommending AS to all men at low risk. They express concern with current guidelines that are inclusive of all patients at good risk. They present data showing that men on AS with more than 2 positive cores of Gleason 6 have a higher rate of reclassification but there is no evidence that these men expedience worse long-term outcomes.
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Histotripsy Treatment of Benign Prostatic Enlargement Using the Vortx Rx System: Initial Human Safety and Efficacy Outcomes

Urology (Gold Journal) In Press - Tue, 01/09/2018 - 00:00
To assess clinical safety (primary) and efficacy (secondary) of histotripsy for treatment of symptomatic benign prostatic enlargement (BPE) in a first-in human study.
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In-Bore 3.0-T Magnetic Resonance Imaging-Guided Transrectal Targeted Prostate Biopsy in a Repeat Biopsy Population: Diagnostic Performance, Complications and Learning Curve

Urology (Gold Journal) In Press - Tue, 01/09/2018 - 00:00
To evaluate the diagnostic performance and complication rate of the in-bore magnetic resonance imaging-guided transrectal targeted prostate biopsy (MRGB) in a repeat biopsy population on basis of a nearly four year learning curve (2014-2017).
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Long-term outcomes of laser prostatectomy for storage symptoms: Comparison of serial 5-year follow-up data between 120W HPS photo-selective vaporization of the prostate and holmium laser enucleation of the prostate

To compare long-term outcomes for storage symptoms between PVP-120W-HPS and HoLEP, and to find factors influencing postoperative improvement of storage symptoms in the long term.
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Neoadjuvant dose dense MVAC versus GC in patients with cT3-4aN0M0 bladder cancer treated with radical cystectomy

Level I evidence supports the utility of neoadjuvant cisplatin-based chemotherapy (NAC) for muscle invasive bladder cancer (BCa). Since dose dense (ddMVAC) has mostly replaced traditional MVAC, we aimed to compare pathological response and survival rates in patients with locally advanced BCa receiving NAC with ddMVAC versus GC.
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What to know about ginger for diarrhea

MedicalNewsToday - Mon, 01/08/2018 - 15:00
A look at ginger for diarrhea, a remedy that has been used for a long time. Included is detail on how much ginger is too much, as how much to eat a day.
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What is hyperphosphatemia?

MedicalNewsToday - Sat, 01/06/2018 - 15:00
Learn all about hyperphosphatemia, when levels of phosphate in the blood are too high. We examine the symptoms, causes, and treatment options.
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Impact of Adjuvant Radiation on Artificial Urinary Sphincter Durability in Post-Prostatectomy Patients

Urology (Gold Journal) In Press - Fri, 01/05/2018 - 00:00
To further understand the implications of adjuvant radiation on artificial urinary sphincter durability (AUS) in post-prostatectomy patients.
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Safety and Feasibility of Intravesical Instillation of Botulinum Toxin-A in Hydrogel-Based Slow Release Delivery System in Interstitial Cystitis/Bladder Pain Syndrome Patients: A Pilot Study

Urology (Gold Journal) In Press - Thu, 01/04/2018 - 00:00
To assess feasibility and safety of a mixture instillation of TC-3 Gel, a novel reverse-thermal gelation hydrogel, and botulinum toxin-A (BTX-A) for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS). TC-3 Gel/BTX-A mix is instilled into the bladder as liquid, solidifies due to body heat and gradually dissolves to release BTX-A for several hours.
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Promescent® Has a Cytotoxic Impact on Fresh Human Sperm in Vitro

Urology (Gold Journal) In Press - Thu, 01/04/2018 - 00:00
To assess the impact of Promescent®, a commonly used topical medication for premature ejaculation (PE), on human sperm motility, forward progression (FP), viability, and sperm DNA fragmentation (SDF) in vitro.
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Comparing outcomes of robotic and open inguinal lymph node dissection in patients with carcinoma penis

To compare outcomes between Robot assisted video endoscopic inguinal lymphadenectomy (RA-VEIL) and open inguinal lymph node dissection (OILND) in patients without bulky nodal metastasis in a tandem contemporary cohort.
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Effect of starting penile rehabilitation with sildenafil immediately after robot-assisted laparoscopic radical prostatectomy on erectile function recovery: a prospective randomized trial

It has not been clearly proven in real practice whether early rehabilitation with phosphodiesterase type 5 inhibitors starting immediately after radical prostatectomy improves erectile function recovery more effectively compared with delayed treatment with the same regimen. We performed a prospective randomised trial to identify this.
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Challenges of multidimensional outcome reporting after suburethral midurethral sling removal

To determine the types and frequency of presenting symptoms in women undergoing sub-urethral mid-urethral sling removal (SSR) towards improving outcome reporting post-SSR.
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Development of a nationally-representative coordinated registry network for prostate ablation technologies

The accumulation of data through a prospective, multi-center coordinated registry network (CRN) is a practical way to gather real world evidence on the performance of novel prostate ablation technologies. Urologic oncologists, targeted biopsy experts, industry representatives, and the Food and Drug Administration (FDA) convened to discuss the role, feasibility, and important data elements of a CRN to assess new and existing prostate ablation technologies.
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