Urology News Feeds

Re-Examining PSA Density: Defining the Optimal PSA Range and Patients for Using PSA Density to Predict Prostate Cancer Using Extended Template Biopsy

Urology (Gold Journal) In Press - Tue, 04/18/2017 - 00:00
To compare the predictive accuracy of PSA density versus PSA across different PSA ranges and by prior biopsy status in a prospective cohort undergoing prostate biopsy.
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Raynaud's Phenomenon: Revisiting a Rare Sign of Pheochromocytoma/Paraganglioma

Urology (Gold Journal) In Press - Tue, 04/18/2017 - 00:00
Paraganglioma (PGL) are rare tumors arising from extraadrenal chromaffin cells and occasionally secret catecholamines. The patient commonly presents with headache, palpitation, anxiety, diaphoresis and episodic or sustained hypertension. Rarely patient can present with Raynaud's phenomenon. We present a case of adolescent girl who presented with isolated Raynaud's phenomenon as only manifestation of metastasis of PGL three years after undergoing surgical excision of normetanephrine secreting abdominal PGL.
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Comparison of Silodosin Monotherapy Versus Silodosin with Tadalafil Add-on Therapy in Patients with Benign Prostatic Hyperplasia

Urology (Gold Journal) In Press - Tue, 04/18/2017 - 00:00
To evaluate the efficacy and safety of add-on therapy with the phosphodiesterase type 5 inhibitor tadalafil for patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia (LUTS/BPH) treated with the α1-adrenoceptor blocker silodosin.
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New “Show Me How” Video Section

Urology (Gold Journal) In Press - Tue, 04/18/2017 - 00:00
We are excited to provide a new opportunity for surgical teams contributing to surgical education by submitting videos dealing with new surgical techniques, tips and tricks, and trouble shooting. The aim is to explore a stepwise approach to surgical innovation (a “Show Me How format”), describe surgical nuances, and present brief outcomes of the technique.
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Does Peak Urine Flow Rate Predict the Development of Incident Lower Urinary Tract Symptoms in Men with Mild to No Current Symptoms? Results from REDUCE

To determine whether decreased peak urine flow is associated with future incident lower urinary tract symptoms (LUTS) in men with mild to no LUTS.
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Malignant Mesothelioma of the Tunica Vaginalis Testis: Outcomes Following Surgical Management Beyond Radical Orchiectomy

Urology (Gold Journal) In Press - Fri, 04/14/2017 - 00:00
Objective:To describe clinical management and outcomes of a cohort of patients with malignant mesothelioma of the tunica vaginalis testis (MMTVT) who received treatments beyond radical orchiectomy.Methods:Patients with confirmed MMTVT at a single tertiary-care institution were identified. Treatments, pathologic outcomes, and survival were recorded. Prognostic variables associated with survival were analyzed with a Cox proportional hazards model and Kaplan-Meier curves.Results:Overall, 15 patients were included.
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Are We Using the Best Tumor Size Cut-Points for Renal Cell Carcinoma Staging?

Urology (Gold Journal) In Press - Thu, 04/13/2017 - 00:00
To compare the predictive ability for oncologic outcomes among current tumor size cut-points and clinically relevant alternatives in order to determine which are optimal.
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Ovotestis in Adolescence: Two Case Reports

Urology (Gold Journal) In Press - Thu, 04/13/2017 - 00:00
We present two patients found to have ovotesticular disorder of sexual differentiation (otDSD) in late adolescence. Two 15-year-old phenotypically male patients presented to a large pediatric hospital with different complaints: one with concern for testicular rupture after a straddle injury; the other with gynecomastia. Further work-up, including imaging and lab tests, was performed before surgical exploration. The first patient had unilateral ovotestis, contralateral testis, and SRY-negative 46,XX karyotype.
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Congenital Aphallia: Novel Use of Acellular Dermal Matrix during Scrotal Flap Phalloplasty

Urology (Gold Journal) In Press - Thu, 04/13/2017 - 00:00
Phallic reconstruction is an important part of management for congenital aphallia. Scrotal flap phalloplasty has been described in pediatric patients to create the appearance of a non-functioning phallus. We describe a modified scrotal flap technique with the addition of an acellular dermal matrix patch (AlloDerm®) to provide additional girth and support to the phallus. The post-operative cosmetic outcome has been satisfactory and there is no documented complication over a 12 month follow-up. Alloderm® dermal matrix can be a safe addition to phallic reconstruction and its overall application needs to be further studied.
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Reply: Cambareri et al: Urology. 2017;101:26-30)

Urology (Gold Journal) In Press - Thu, 04/13/2017 - 00:00
We read with much interest the article entitled “Do Overweight and Obese Pediatric Stone Formers Have Differences in Metabolic Abnormalities Compared with Normal-weight Stone Formers?” by Cambareri et al.1 At this juncture, we take this opportunity to express our scientific views on the published article.
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Metabolic Syndrome Does Not Increase the Risk of Ejaculatory Dysfunction in Patients with Lower Urinary Tract Symptoms and Benign Prostatic Enlargement: an Italian Single Center Cohort Study

Urology (Gold Journal) In Press - Thu, 04/13/2017 - 00:00
To evaluate the relationship between metabolic syndrome and ejaculatory dysfunction in patients with lower urinary tract symptoms (LUTS) and benign prostatic enlargement (BPE).
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Do Overweight and Obese Pediatric Stone Formers Have Differences In Metabolic Abnormalities Compared With Normal Weight Stone Formers?

Urology (Gold Journal) In Press - Thu, 04/13/2017 - 00:00
Our study may serve as a geographically widespread analysis of stone disease in at risk children but we acknowledge that it is only a reference point and not the definitive study in this subject area. We agree that dietary information is necessary to put these findings in complete context and offer a potential road map to dietary modification as the ideal method to prevent de novo and recurrent stone disease. This is one of the primary aims of our prospective multi-institutional collaboration CUP (Collaborative in Urolothiasis in Pediatrics) which involves pediatric Urology and Nephrology specialists from 7 institutions around the country and will continue to leverage data from standardized 24 hour urine collections from a diverse pediatric population.
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This Month in Adult Urology

When partial nephrectomy is planned, conversion to radical nephrectomy is a possibility regardless of surgical approach. With a laparoscopic or robotic approach, complete kidney removal typically can be accomplished without conversion to open surgery. In this retrospective analysis of 1,023 planned robotic partial nephrectomies by Kara et al (page 000) from Cleveland, Ohio conversion to radical nephrectomy was necessary in 32 patients (3.1%).1 Tumor related factors, such as hilar involvement, positive margins or advanced disease stage, were the most common reasons for conversion but failure to improve was the reason in 5 cases.
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This Month in Pediatric Urology

Although typically thought of as an adult issue, management decisions of pediatric conditions, such as varicocele surgery and exposure to gonadotoxins, in childhood and adolescence can have direct consequences as well as long-term effects on fertility. Currently, for these patients the options are limited but there are now advances in fertility preservation which hold great promise.
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Re: Vitamin B12 Deficiency in Patients after Enterocystoplasty

A. Keenan, B. Whittam, R. Rink, M. Kaefer, R. Misseri, S. King and M. Cain
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Re: The Anatomic Findings during Operative Exploration for Non-Palpable Testes: A Prospective Evaluation

K. W. Gonzalez, B. G. Dalton, C. L. Snyder, C. M. Leys, S. D. St. Peter and D. J. Ostlie
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Re: Targeted Molecular-Genetic Imaging and Ligand-Directed Therapy in Aggressive Variant Prostate Cancer

F. Ferrara, D. I. Staquicini, W. H. Driessen, S. D’Angelo, A. S. Dobroff, M. Barry, L. C. Lomo, F. I. Staquicini, M. Cardó-Vila, S. Soghomonyan, M. M. Alauddin, L. G. Flores, II, M. A. Arap, R. C. Lauer, P. Mathew, E. Efstathiou, A. M. Aparicio, P. Troncoso, N. M. Navone, C. J. Logothetis, S. Marchiò, J. G. Gelovani, R. L. Sidman, R. Pasqualini and W. Arap
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