Urology News Feeds

Altered angiogenic growth factors in urine of prostate cancer survivors with radiation history and radiation cystitis

Urology (Gold Journal) In Press - Fri, 07/27/2018 - 00:00
To determine if the vascular damage in bladders of prostate cancer survivors with radiation cystitis can be detected through altered angiogenic growth factors in urine.
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An Evaluation of Reported Follicle Stimulating Hormone, Luteinizing Hormone, Estradiol and Prolactin Reference Ranges in the United States.

Urology (Gold Journal) In Press - Fri, 07/27/2018 - 00:00
To characterize US clinical laboratory reference range reporting and testing methods of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, prolactin.
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Multi-institutional prospective analysis of intralesional injection of Collagenase Clostridium Histolyticum, tunical plication and partial plaque excision and grafting for the management of Peyronie's disease

Urology (Gold Journal) In Press - Fri, 07/27/2018 - 00:00
To compare in a prospective, non-randomized fashion the outcomes of Collagenase Clostridium Histolyticum (CCH) and surgical interventions (tunical plication [TP] and partial plaque excision and grafting [PEG]) in patients with PD. Intralesional injection of CCH is the only Food and Drug Administration-approved non-surgical intervention for Peyronie's disease (PD).
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Chronic Prostatitis/Chronic Pelvic Pain as a Psycho-Neuromuscular Disorder–A Meta-analysis

Urology (Gold Journal) In Press - Fri, 07/27/2018 - 00:00
To evaluate effectiveness of physical therapy, biofeedback, and/or cognitive behavioral therapy for Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS). This symptom complex has resisted resolution from conventional urologic treatment of the prostate, which includes antibiotics, alpha-blockers, and analgesics. Beginning in 1995, a new paradigm was introduced viewing CP/CPPS as a psycho-neuromuscular disorder driven by protective pelvic floor guarding and psychosocial stress.
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Determinants of Active Surveillance in Patients with Small Renal Masses

Urology (Gold Journal) In Press - Fri, 07/27/2018 - 00:00
To evaluate trends in the utilization of active surveillance (AS) in a nationally representative cancer database. AS has been increasingly recognized as a strategy for patients with small renal masses (SRM), but little is known about national usage patterns.
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Evaluation of Cancer-Specific Mortality with Surgery Versus Radiation as Primary Therapy for Localized High-Grade Prostate Cancer in Men Younger than 60 Years Old

The optimal primary treatment for localized high-grade prostate cancer in younger men remains controversial. The objective of this project was to compare the impact of initial radical prostatectomy versus radiation therapy on survival outcomes for young men <60 years old with high-grade prostate cancer.
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Gender Equivalence in Prevalence of Nephrolithiasis among Adults under 50 Years of Age in the United States

Although urolithiasis affects both sexes, conventional teaching proposes that men are 3x more likely to suffer from stones. Clinical practice however refutes such disparity, particularly among working-aged adults. Small studies have suggested an erosion of this gender gap. We therefore sought to examine the relationship between gender and stone prevalence among U.S. adults <50.
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Conversion from Cystine to Non-cystine Stones: Incidence and Associated Factors

and Objectives: Cystinuric patients are often treated with medical alkanalization and shockwave lithotripsy – both are hypothesized to increase the risk of calcium phosphate stones. We performed a multi-center retrospective review to evaluate whether patients with cystinuria develop stones of other composition and with what frequency.
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A contemporary analysis of dual inflatable penile prosthesis and artificial urinary sphincters outcomes

Inflatable penile prostheses (IPP) and artificial urinary sphincters (AUS) are used to treat men with erectile dysfunction (ED) and stress urinary incontinence (SUI), respectively. After treatment of prostate cancer, men often experience ED and SUI. Dual prosthetic implantation can improve the quality of life of these men. We evaluated the reoperation outcomes in men who underwent dual implantation compared to each individually.
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Foods to eat and avoid on a low-purine diet

MedicalNewsToday - Thu, 07/26/2018 - 18:00
People who have gout, kidney stones, or a similar disorder can often benefit from following a low-purine diet. Purine is a naturally occurring substance, and too much can lead to a buildup of uric acid. In this article, learn which foods to eat and which to avoid to reduce levels of purine in the body.
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Editorial Comment

The authors report the prospective implementation of an ERAS protocol for children undergoing urinary tract reconstruction with small bowel. In this small-scale study 15 patients treated after implementation of an ERAS protocol had shorter time to flatus, stool and discharge home compared to 15 patients treated before intervention. Although adult focused ERAS protocols have been described for various abdominal surgeries,1,2 this study reveals that an ERAS protocol can be successfully used in children despite the variability in physiology, social factors and evidence strength in the 2 populations.
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Editorial Comment

“Winds of change” blow for prostate cancer diagnostics. Recently published data from the PRECISION (Prostate Evaluation for Clinically Important Disease: Sampling Using Image guidance or Not?) trial clearly emphasize the role of targeted biopsies over systematic biopsies (reference 1 in article). Some are ready to rely on MRI and discard routine systematic biopsies while some are more hesitant and still consider systematic biopsies essential.
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Younger Men with Prostate Cancer have Lower Risk of Upgrading while on Active Surveillance: A Meta-analysis and Systematic Review of the Literature

Urology (Gold Journal) In Press - Thu, 07/26/2018 - 00:00
Active surveillance (AS) has become a popular option for patients with low risk prostate cancer. Our objective was to examine the correlation between age and the risk of Gleason upgrading and biopsy progression. A systematic search was conducted. Eight studies met our eligibility criteria including 6,522 patients with median age of 65.8 (41-86) years. Per decade decrease in age, the pooled OR and HR (CI 95%) for Gleason upgrading were 0.83 (0.73-0.94) and 0.87 (0.82-0.92), and for biopsy progression were 0.80 (0.74-0.86) and 0.88 (0.79-0.99), respectively.
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