Urology News Feeds
A 17-gene Panel for Prediction of Adverse Prostate Cancer Pathologic Features: Prospective Clinical Validation and Utility
To validate the 17-gene Oncotype DX Genomic Prostate Score® (GPSTM) biopsy-based gene expression assay as a predictor of adverse pathology (AP, Gleason score [pGS] ≥ 4+3 and/or ≥ pT3) in a prospectively enrolled cohort.
To describe the annual volume of pediatric urology cases in an academic, tertiary care setting.
Extrarenal Wilms tumor (ERWT) is rare. We describe the first reported case of primary paratesticular ERWT with regional metastasis in 8-month old male with left undescended testis. Patient underwent left radical orchiectomy with regional lymph node excision. The inguinal node and paratesticular mass demonstrated the classic Wilms triphasic pattern, stained positively for WT-1 and demonstrated no loss of heterozygosity of chromosomes 1p and 16q. Work-up was negative for primary renal Wilms tumor or distant metastasis.
Inconsistent Adoption of World Health Organization V (2010) Semen Analysis Reference Ranges in the United States Six Years After Publication
To determine the percentage of laboratories in the United States that have adopted the World Health Organization 2010 (WHO 5) semen analysis (SA) reference values six years after their publication.
To conduct a comprehensive assessment of sexual function of patients undergoing surgical treatment of penile fracture (PF), covering psychological aspects related to trauma.
Concerns with “New Evidence for the Benefits of Prostate-specific Antigen Screening: Data from 400,887 Kaiser Permanente Patients”
To the Editor: I read with interest the recent retrospective cohort review of prostate-specific antigen (PSA) screening, and was impressed with the effort to quantify screening benefits.1 This was an innovative means of studying this important topic. However, three study assumptions create errors that call the conclusions into doubt.
Before detailing my responses, I want to say that in the commentator's reading of my data tables there seem to be some misinterpretations, and in his estimate of the potential impact of the noted problems, the likely effect is greatly exaggerated. In addition, he fails to look at the concordance between this study and others using similar parameters and testing intervals – the cumulative across study analysis that is as important in a scientific approach as the hunt for potentially problematic imperfections.
To compare outcome of muscle and nerve-sparing bulbar urethroplasty with standard bulbar urethroplasty as regard ejaculatory dysfunction and post–void dribbling.
A 73-year-old female with a past medical history significant for hypertension, diabetes mellitus II, and past smoking history presented to her Gynecologist for vaginal pain and hematuria that had been persistent for 1 month. Physical exam revealed a 3 cm urethral mass palpable along the anterior vaginal wall. Office biopsy was taken which revealed malignant spindle cell neoplasm. She was then referred to Urology for further management.
The use of 3-dimensional, virtual reality models for surgical planning of robotic partial nephrectomy
To determine whether 3-dimensional, virtual reality models of patient-specific anatomy improve outcomes in patients undergoing robotic partial nephrectomy.
Germ Cell Testicular Tumors – Contemporary Diagnosis, Staging and Management of Localized and Advanced disease
Germ cell testicular tumors (GCTTs) are the most commonly diagnosed cancer in young men, with cure rates exceeding 95%. Clinical stage 1 (CS1) disease is the most common manifestation, with radical orchiectomy curing the majority of CS1 patients, making active surveillance the treatment of choice, with a cancer specific survival nearing 100% and low relapse rates. However, in metastatic disease, chemotherapy, radiotherapy and surgery are curative options. Chemotherapy remains the mainstay of therapy for advanced disease with surgical management of residual disease.
Adult Wilms tumor (WT) is a well-known, albeit rare entity and has historically been associated with worse overall clinical outcomes when compared to younger patients. Because WT is uncommon in adult patients, it is often misdiagnosed and treated off standardized pediatric protocols. WT associated with pregnancy is even more rare, and there is not a standardized approach to this small subset of patients. We present a case of an adult WT discovered and managed during the perinatal period and review prior published cases.
Application of a functional three-dimensional perfusion model in laparoscopic partial nephrectomy with precise segmental renal artery clamping
To assess the feasibility of a novel functional perfusion model based on enhanced computed tomography (CT) for the evaluation of split renal function and orientation of segmental renal artery clamping during laparoscopic partial nephrectomy (LPN).
Herlyn-Werner-Wunderlich syndrome: report of a prenatally recognised case and review of the literature
Herlyn-Werner-Wunderlich syndrome (HWWS), defined by the triad of uterus didelphys, obstructed hemivagina and ipsilateral renal agenesis, is a rare Mullerian malformation, usually diagnosed after menarche, when symptoms related to hematocolpos arise. Rarely, this malformation is diagnosed in the neonatal period, normally following prenatal diagnosis of renal agenesis. Herein, a case recognised on prenatal imagiology that underwent surgery on the 4th day of life is reported. The records of prepubertal cases were also collected, addressing the clinical and imagiological features.
To evaluate differences in prevalence, OAB risk factors, and OAB treatment in a diverse population of underrepresented racial/ethnic groups.
The 3-D volumetric measurement including resected specimen for predicting renal function after robot-assisted partial nephrectomy
To investigate the relationship between postoperative renal function and resected cortex margin volume calculated by a 3-dimensional reconstruction technique based on the resected specimen, and to determine predictors of renal function after robot-assisted partial nephrectomy.
Although it was first reported by Fallopius in 1561, Peyronie's disease (PD) bears the name of Francois de la Peyronie who reported a case in 1743.1 PD is characterized by penile induration, nodule, or plaque resulting in erectile deformity. Although PD is frequently linked to erectile dysfunction (ED), it is not clear how often it is or which comes first. Mulhall states “Elucidating the role preexisting ED plays in the development of PD remains a difficult task, as ED is also a known sequel of PD.
Failure of angiographic management in cases of post renal intervention bleed: Risk factors and management approach
To evaluate the factors predicting the risk for failed angiographic management (AM), we retrospectively studied cases of Digital Subtraction Angiography (DSA) and super-selective angiography (SSA) to control severe/delayed bleeding following renal interventions, which may otherwise be life threatening and often require nephrectomy.
Non-closure versus closure of buccal mucosal graft harvest site: A systematic review and meta-analysis of patient-reported outcomes
To compare the post-procedural oral pain scale and other patient reported oral morbidities for non-closure versus closure of buccal mucosal graft (BMG) harvest sites through systematic review and meta-analysis of comparative studies.
Cost Effectiveness of the Oncotype DX Genomic Prostate Score for Guiding Treatment Decisions in Patients With Early Stage Prostate Cancer
To determine the cost-effectiveness of using the Oncotype DX Genomic Prostate Score (GPS), a 17-gene expression assay that can be used to inform decisions regarding active surveillance (AS) versus immediate treatment.