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Up staging of clinical T1 RCC occurs when tumors invade small branches of renal veins or fat surrounding the kidney. Similar to prior studies (reference 3 in article) Shah et al describe an 11% risk of pathological up staging. Interestingly they found a higher recurrence risk in up staged cases following partial vs radical nephrectomy. After partial nephrectomy most recurrences were local, which may be amenable to curative local therapy and associated with favorable cancer specific survival in the absence of distant metastasis.
We appreciate the comment and recognize the pioneering work of Dr. Parsons in the 1990s (references 1 and 2 in comment). In our preliminary work principal component analysis and unsupervised hierarchical clustering showed a clear separation between gene expression profiles in bladder biopsy tissues from subjects with low capacity (400 ml or less) compared to those with bladder capacity greater than 400 ml (reference 12 in article). These data are consistent with a bladder centric disease phenotype.
These authors report BC while under anesthesia in more than 100 patients with IC. Results show that BC was inversely proportional to patient reported symptoms on several questionnaires and to age. The key message is that patients who are older have more bladder symptoms and lower BC, and we reported similar results.1 This message is critical because it emphasizes that IC is a chronic disease that begins when the symptoms are milder and intermittent. With time symptoms increase and bladder capacity decreases because the disease is destroying the bladder.
As many as a third of adults with type 2 diabetes do not know they have it. In this article, learn about the common signs of uncontrolled diabetes.
W. Ma, S. Li, S. Ma, L. Jia, F. Zhang, Y. Zhang, J. Zhang, G. Wong, S. Zhang, X. Lu, M. Liu, J. Yan, W. Li, C. Qin, D. Han, C. Qin, N. Wang, X. Li and G. F. Gao
U. Y. Schaff, L. L. Fredriksen, J. G. Epperson, T. R. Quebral, S. Naab, M. J. Sarno, M. L. Eisenberg and G. J. Sommer
Re: Men’s Knowledge of Their Own Fertility: A Population-Based Survey Examining the Awareness of Factors That Are Associated with Male Infertility
D. Daumler, P. Chan, K. C. Lo, J. Takefman and P. Zelkowitz
P. Jóźków, M. Mędraś, F. Lwow, A. Zagrodna and M. Słowińska-Lisowska
Re: Moderate Aerobic Exercise Training for Improving Reproductive Function in Infertile Patients: A Randomized Controlled Trial
B. Hajizadeh Maleki and B. Tartibian
When Should we Offer Parasacral Transcutaneous Electrical Nerve Stimulation for Pediatric Patients with Lower Urinary Tract Dysfunction?
Lower urinary tract (LUT) dysfunction in children has a broad spectrum of presentation. Patients may experience symptoms related to overactive bladder (OAB), voiding postponement, dysfunctional voiding (DV) or underactive bladder (UAB). Using the same treatment method will seldom have the same effective action under these different conditions when there are perhaps different pathophysiological etiologies.
To identify if any pre-operative variable are associated with post-operative complications after pediatric sacral neuromodulation (SNM).
To determine if the histopathology of the ureteropelvic junction differs between those with and without crossing vessels who present with a ureteropelvic junction obstruction.
Re: Influence of Voluntary Pelvic Floor Muscle Contraction and Pelvic Floor Muscle Training on Urethral Closure Pressures: A Systematic Literature Review
M. Zubieta, R. L. Carr, M. J. Drake and K. Bø
J. J. Wyndaele
K. Saeki, K. Obayashi and N. Kurumatani
Re: Symptom Improvement after Prolapse and Incontinence Graft Removal in a Case Series of 306 Patients
L. Rogo-Gupta, T. Grisales, L. Huynh, L. V. Rodríguez and S. Raz
Re: Sacral Neuromodulation: An Effective Treatment for Lower Urinary Tract Symptoms in Multiple Sclerosis
F. Puccini, A. Bhide, S. Elneil and G. A. Digesu
Re: Understanding the Use of Prostate Biopsy among Men with Limited Life Expectancy in a Statewide Quality Improvement Collaborative
F. Abdollah, Z. Ye, D. C. Miller, S. M. Linsell, J. E. Montie, J. O. Peabody and K. R. Ghani; Michigan Urological Surgery Improvement Collaborative
Re: Complications and Quality of Life in Elderly Patients with Several Comorbidities Undergoing Cutaneous Ureterostomy with Single Stoma or Ileal Conduit after Radical Cystectomy
N. Longo, C. Imbimbo, F. Fusco, V. Ficarra, F. Mangiapia, G. Di Lorenzo, M. Creta, V. Imperatore and V. Mirone