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Editorial Comment

Up staging of clinical T1 RCC occurs when tumors invade small branches of renal veins or fat surrounding the kidney. Similar to prior studies (reference 3 in article) Shah et al describe an 11% risk of pathological up staging. Interestingly they found a higher recurrence risk in up staged cases following partial vs radical nephrectomy. After partial nephrectomy most recurrences were local, which may be amenable to curative local therapy and associated with favorable cancer specific survival in the absence of distant metastasis.
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Reply by Authors

We appreciate the comment and recognize the pioneering work of Dr. Parsons in the 1990s (references 1 and 2 in comment). In our preliminary work principal component analysis and unsupervised hierarchical clustering showed a clear separation between gene expression profiles in bladder biopsy tissues from subjects with low capacity (400 ml or less) compared to those with bladder capacity greater than 400 ml (reference 12 in article). These data are consistent with a bladder centric disease phenotype.
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Editorial Comment

These authors report BC while under anesthesia in more than 100 patients with IC. Results show that BC was inversely proportional to patient reported symptoms on several questionnaires and to age. The key message is that patients who are older have more bladder symptoms and lower BC, and we reported similar results.1 This message is critical because it emphasizes that IC is a chronic disease that begins when the symptoms are milder and intermittent. With time symptoms increase and bladder capacity decreases because the disease is destroying the bladder.
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Ten signs of uncontrolled diabetes

MedicalNewsToday - Tue, 05/16/2017 - 02:00
As many as a third of adults with type 2 diabetes do not know they have it. In this article, learn about the common signs of uncontrolled diabetes.
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Re: Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice

W. Ma, S. Li, S. Ma, L. Jia, F. Zhang, Y. Zhang, J. Zhang, G. Wong, S. Zhang, X. Lu, M. Liu, J. Yan, W. Li, C. Qin, D. Han, C. Qin, N. Wang, X. Li and G. F. Gao
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Re: Novel Centrifugal Technology for Measuring Sperm Concentration in the Home

U. Y. Schaff, L. L. Fredriksen, J. G. Epperson, T. R. Quebral, S. Naab, M. J. Sarno, M. L. Eisenberg and G. J. Sommer
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Re: Associations between Physical Activity and Semen Quality in Young Healthy Men

P. Jóźków, M. Mędraś, F. Lwow, A. Zagrodna and M. Słowińska-Lisowska
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When Should we Offer Parasacral Transcutaneous Electrical Nerve Stimulation for Pediatric Patients with Lower Urinary Tract Dysfunction?

Lower urinary tract (LUT) dysfunction in children has a broad spectrum of presentation. Patients may experience symptoms related to overactive bladder (OAB), voiding postponement, dysfunctional voiding (DV) or underactive bladder (UAB). Using the same treatment method will seldom have the same effective action under these different conditions when there are perhaps different pathophysiological etiologies.
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Factors Predicting Complications after Sacral Neuromodulation in Children

Urology (Gold Journal) In Press - Tue, 05/16/2017 - 00:00
To identify if any pre-operative variable are associated with post-operative complications after pediatric sacral neuromodulation (SNM).
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Histopathology in Ureteropelvic Junction Obstruction with and Without Crossing Vessels

Urology (Gold Journal) In Press - Tue, 05/16/2017 - 00:00
To determine if the histopathology of the ureteropelvic junction differs between those with and without crossing vessels who present with a ureteropelvic junction obstruction.
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Re: Understanding the Use of Prostate Biopsy among Men with Limited Life Expectancy in a Statewide Quality Improvement Collaborative

F. Abdollah, Z. Ye, D. C. Miller, S. M. Linsell, J. E. Montie, J. O. Peabody and K. R. Ghani; Michigan Urological Surgery Improvement Collaborative
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