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Editorial Comment

This double-blind, placebo controlled, randomized study ultimately shows that hyperbaric oxygen therapy does not improve erectile recovery in men with baseline normal erections following robotic prostatectomy. The silver lining in this study is that 18-month outcomes revealed a net change from median baseline function based on the IIEF score of 30/30 to 28/30 and 21/30 (a nonsignificant difference) in the placebo and treatment groups, respectively. These post-prostatectomy erectile function outcomes are quite good and advocate for a post-prostatectomy regimen of 50 mg sildenafil daily for 1 year as performed in the trial.
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Video Endoscopic Inguinal Lymphadenectomy Versus Open Inguinal Lymphadenectomy for Carcinoma Penis: Expanding Role and Comparison of Outcomes

Urology (Gold Journal) In Press - Thu, 11/16/2017 - 00:00
To compare differences of morbidity profile, oncological yield & efficacy between video endoscopic inguinal lymphadenectomy and open inguinal lymphadenectomy cases.
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Ultrasound-Guided Pudendal Block is a Viable Alternative to Caudal Block for Hypospadias Surgery: a Single Surgeon Pilot Study

Urology (Gold Journal) In Press - Thu, 11/16/2017 - 00:00
To evaluate pudendal nerve block as an alternative to caudal block for hypospadias surgery.
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A Case of Prenatally Diagnosed Wilms' Tumor Managed with Laparoscopic Nephrectomy

Urology (Gold Journal) In Press - Thu, 11/16/2017 - 00:00
We present a case of prenatally diagnosed Wilms' tumor, subsequent operative approach and management. The patient was referred to our institution with an abnormal prenatal renal ultrasound. CT scan after delivery showed a multifocal enhancing left renal mass. She underwent an uncomplicated left laparoscopic radical nephrectomy and retroperitoneal lymph node sampling using a novel hidden incision endoscopic surgery (HIdES) technique. Final pathology revealed favorable histology Stage II Wilms' Tumor.
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When Chemotherapy is Not Enough – Management of Prostatic Embryonal Rhabdomyosarcoma in an Infant

Urology (Gold Journal) In Press - Thu, 11/16/2017 - 00:00
A baby boy was diagnosed with embryonal rhabdomyosarcoma causing left hydroureteronephrosis. A loop ureterostomy was performed, and he was treated per the RMS13 protocol. After three months of chemotherapy, his tumor burden increased, and he underwent radical cystoprostatectomy and right-to-left transureteroureterostomy (end-to-end fashion utilizing the distal limb of his ureterostomy). This innovative method was utilized because the child's tumor burden was too large to be treated effectively and safely with radiation.
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A Case of Spontaneous Bilateral Renal Artery Dissection Following Robotic Surgery

Urology (Gold Journal) In Press - Thu, 11/16/2017 - 00:00
Our patient is an otherwise well 69-year-old man who represented to hospital two days following an uncomplicated Robotic Assisted Laparoscopic Prostatectomy (RALP).
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Unreliability of the Duplex Scan in Diagnosing Corporeal Venous Occlusive Disease (CVOD) in Young Healthy Males with Erectile Deficiency (ED)

Urology (Gold Journal) In Press - Thu, 11/16/2017 - 00:00
To define the role of cavernosal venous occlusive dysfunction (CVOD) as the only cause of erectile dysfunction (ED).
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Reply to: Deep Infiltrating Endometriosis-Urinary Tract Involvement and Predictive Factors for Major Surgery. Freire Mj, Dinis Pj, Medeiros R, Sousa L, Águas F, Figueiredo A. Urology. 2017 Oct;108:65-70. Doi: 10.1016/J.Urology.2017.06.039. Epub 2017 Jul 8

Urology (Gold Journal) In Press - Thu, 11/16/2017 - 00:00
We appreciate this study which results according to the literature. It is clear that ureteral or bladder endometriosis could lead to a silent loss of renal function. ” A relatively limited number of patients who are currently not considered to be at true risk of urinary involvement have possible late diagnosis of renal failure.”1 Early diagnosis of hydronephrosis is critical to preserve renal function in these young patients. “As such we believe that patients with suspected or proven pelvic endometriosis should systematically undergo a sonographic kidney evaluation during routine gynecological sonographic examination, because of the high frequency of silent presentations”.
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Use of Routine Home Health Care and Deviations From an Uncomplicated Recovery Pathway after Radical Prostatectomy

Urology (Gold Journal) In Press - Thu, 11/16/2017 - 00:00
To evaluate the statistical association between routine home health use after prostatectomy, short-term surgical outcomes, and payments.
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Is Removal of the Pressure Regulating Balloon Necessary after Artificial Urinary Sphincter Cuff Erosion?

Urology (Gold Journal) In Press - Thu, 11/16/2017 - 00:00
To characterize the risk of delayed infectious complications from retained pressure regulating balloons (PRB) after artificial urinary sphincter (AUS) cuff erosion.
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External Genital Development, Urethra Formation and Hypospadias Induction in Guinea Pig: a Double Zipper Model for Human Urethral Development

Urology (Gold Journal) In Press - Thu, 11/16/2017 - 00:00
To determine whether the guinea pig phallus would be an appropriate model of human penile development, we characterized the embryology and sexual differentiation of guinea pig external genitalia and attend to induce hypospadias in males and tubular urethra formation in females pharmacologically.
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Prediction of Prostate Cancer Risk among Men Undergoing Combined MRI-Targeted and Systematic Biopsy Using Novel Pre-Biopsy Nomograms That Incorporate MRI Findings.

Urology (Gold Journal) In Press - Thu, 11/16/2017 - 00:00
To develop nomograms that predict the probability of overall PCa and clinically significant PCa (Gleason ≥7) on MRI targeted, and combined MRI-targeted and systematic, prostate biopsy.
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Financial Toxicity in Bladder Cancer Patients- Reasons for Delay in Care and Effect on Quality of Life

Costly surveillance and treatment of bladder cancer can lead to financial toxicity (FT), a treatment-related financial burden. Our objective was to define the prevalence of FT among bladder cancer patients and identify delays in care and its effect on health-related quality of life (HRQOL).
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Reply by Authors

We agree. Most patients with urethral stricture have diminished quality of life and this is often the primary reason for selecting urethroplasty as a treatment option. However, many patients also experience adverse health outcomes due to urethral stricture while awaiting treatment and will continue to require health care resources. This must also be considered when allocating operative resources globally.
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Editorial Comment

Keith et al present an apt study analyzing complications in patients awaiting urethroplasty. The study covers 5 years and significant numbers. Patients with urethral structure can experience urine retention or have urinary tract infections. The poorer the flow, the earlier should be the reconstruction.
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Reply by Authors

It is reassuring to read that our innovation should not be “ridiculed” or “violently opposed” and we hope the Journal readership shares this assessment after reviewing our work. We accept the responsibility of regularly updating this report, providing information that describes issues that may not be self-evident with modest monitoring.1
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Editorial Comment

“All truth passes through three stages. First, it is ridiculed. Second, it is violently opposed. Third, it is accepted as being self-evident.” Innovations in medicine arise from challenging accepted traditions, and this quote (often attributed to Schopenhauer) may describe many innovations in the past, present and future. The authors report clinical outcomes of an innovation, ureteral clipping for low or nonfunctioning renal moieties, after previously reporting a smaller series (reference 4 in article).
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Risk of upgrading from prostate biopsy to radical prostatectomy pathology: Does Saturation Biopsy of Index Lesion during mpMRI-TRUS fusion biopsy help?

To determine if ‘saturation’ of the index-lesion during MRI-TRUS fusion-guided (fusion) biopsy decreases rate of pathological upgrade from biopsy to radical-prostatectomy (RP).
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Incidence of Extra-Prostatic Extension at Radical Prostatectomy with Pure Gleason Score 3+3=6 (Grade Group 1) Cancer: Implications for Whether Gleason Score 6 Prostate Cancer Should be Renamed as "not Cancer" and for Selection Criteria for Active...

To assess the risk of locally aggressive behavior in pure Gleason Score 6 (GS6) (Grade Group 1) prostate cancer, using contemporary grading criteria, which has only been studied in one prior cohort.
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EGFR Family Inhibition Identifies P38 MAPK as a Potential Therapeutic Target in Bladder Cancer

Urology (Gold Journal) In Press - Wed, 11/15/2017 - 00:00
ObjectiveTo investigate perturbations in downstream signalling pathway activation and potential resistance mechanisms to EGFR and/or HER2 inhibition in cell line models of bladder cancer.MethodsWe undertook a structured screening approach by phosphokinase array, followed by validation steps, to detect activated downstream signalling pathway nodes after therapeutic inhibition of EGFR and/or HER2 in bladder cancer cell lines.ResultsErlotinib treatment of RT112 cells induced phosphorylation of 9 activated phospho-protein targets (p38 MAPK (Thr180/Tyr182), GSK-3α/β (Ser21/9), MEK1/2 (Ser218/222, Ser222/226), Akt (Ser473), TOR (Ser2448), Src (Tyr419), p27 (Thr198), p27 (Thr157) and PLCγ-1 (Tyr783)) whereas STAT4 (Tyr693) phosphorylation was reduced.
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